Development and Validation of HPTLC Method for Estimation of Propranolol Hydrochloride and Flunarizine Dihydrochloride in Combined Dosage Form

Table 3

Robustness studies.

Method parameter/condition	Deliberate changes	% RSD of peak area (𝑛=3)
		PRO	FLU
Chamber saturation time^(a)	20 min	0.93	0.67
	40 min	1.13	0.98
Development distance from spot application^(b)	75 mm	0.39	0.86
	85 mm	0.98	1.16

^(a)±20% change in set time.
^(b)±10% change in set distance.