Assessment of Histopathological Response in Gastric and Gastro-Oesophageal Junction Adenocarcinoma following Neoadjuvant Chemotherapy: Which Scoring System to Use?

Table 1

Histological response criteria following neoadjuvant chemotherapy in gastric cancers.

Reference	Scores	Criteria
	TRG 1	Absence of residual cancer and fibrosis extending through the layers of oesophageal wall
	TRG 2	Presence of rare residual cancer cells
Mandard et al. [7]	TRG 3	Increase in number of residual cancer cells, but fibrosis still predominant
	TRG 4	Showing residual cancer out-growing fibrosis
	TRG 5	Absence of regressive changes
	Grade 0	No change ± neither necrosis nor cellular or structural change can be seen throughout the lesion
Ninomiya et al. [10]	Grade 1	1(a) Necrosis or disappearance of the tumour is present in less than 1/3 of the whole lesion; 1(b) Necrosis or disappearance of the tumour is present in no more than 2/3 of the whole lesion
	Grade 2	Moderate change ± necrosis or disappearance of the tumour is present in more than 2/3 of the whole lesion, but viable tumour cells remain.
	Grade 3	Marked change ± the whole lesion falls into necrosis and/or is replaced by fibrosis, with or without granulomatous changes. No viable tumour cells.
Becker et al. [11]	1A	No residual tumour/tumour bed
	1B	<10% tumour cells
	2	10–50% residual tumour/tumour bed
	3	>50% no signs of neoplastic regression