Assessment of Histopathological Response in Gastric and Gastro-Oesophageal Junction Adenocarcinoma following Neoadjuvant Chemotherapy: Which Scoring System to Use?
Table 1
Histological response criteria following neoadjuvant chemotherapy in gastric cancers.
Reference
Scores
Criteria
TRG 1
Absence of residual cancer and fibrosis extending through the layers of oesophageal wall
1(a) Necrosis or disappearance of the tumour is present in less than 1/3 of the whole lesion 1(b) Necrosis or disappearance of the tumour is present in no more than 2/3 of the whole lesion
Grade 2
Moderate change ± necrosis or disappearance of the tumour is present in more than 2/3 of the whole lesion, but viable tumour cells remain.
Grade 3
Marked change ± the whole lesion falls into necrosis and/or is replaced by fibrosis, with or without granulomatous changes. No viable tumour cells.