Table of Contents
ISRN Hematology
Volume 2012, Article ID 524040, 7 pages
Review Article

Evaluation of Transfusion Pyrexia: A Review of Differential Diagnosis and Management

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada T6G 2R3

Received 21 August 2012; Accepted 7 September 2012

Academic Editors: G. Carulli, A. Pekrun, B. Wachowicz, and A. M. Will

Copyright © 2012 Oladimeji P. Arewa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background/purpose. Transfusion pyrexia (fever) is an important clinical sign/symptom occurring either as an isolated event or as part of a constellation of signs and symptoms in relation to blood transfusion. It is an important cause of morbidity and may be an important sign of life-threatening complications of blood transfusion. Pyrexia is often a reason for the discontinuation of a blood transfusion episode, and adequate evaluation remains a challenge for clinicians. The decision to stop a blood transfusion episode on account of fever is often a difficult one. This paper reviews the differential diagnosis of transfusion pyrexia (TP), the pathogenesis as well as current management measures. Study selection and data source. Literature sources include medical texts, journals, dissertations, and internet-based electronic materials Results and conclusion. Adequate evaluation of pyrexia accompanying blood transfusion remains a challenge for clinicians. An algorithm to assist the clinician in the evaluation of fever occurring in a blood transfusion recipient is developed and presented. Continuous medical education is necessary for clinicians towards improved patient care in transfusion medicine.