Table of Contents
ISRN Organic Chemistry
Volume 2012, Article ID 526867, 4 pages
Research Article

New Way of Direct Nitrogen Atom Phenylation in Quinoline Derivatives

1Laboratory of Radiochemistry, Natural Sciences Institute, Perm State University, Perm 614990, Russia
2Chemistry Department, Saint Petersburg State University, 26 Universitetsky Pr., Petrodvorets, Saint Petersburg 198504, Russia
3Radiochemistry Department, M. V. Lomonosov Moscow State University, Leninskie Gory, Moscow 119992, Russia
4Department of Chemistry, James Madison University, Harrisonburg, VA 22807, USA
5Department of Organic Chemistry, Perm State University, Perm 614990, Russia

Received 20 April 2012; Accepted 15 May 2012

Academic Editors: A. Hajra and J. A. Palenzuela

Copyright © 2012 Nadezhda E. Shchepina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Comparison of ion-molecular reactions of free-phenyl cations generated by tritium β-decay with 2-methyl- and 2-phenylquinolines has been investigated. The reaction of direct nitrogen atom phenylation with the help of nucleogenic phenyl cations has been fulfilled for the first time and a new one-step synthesis of tritium-labeled N-phenyl-2-phenylquinolinium salt—lipophilic radioactive biological marker has been elaborated.