Bioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Pharmacokinetic <br/>parameter</td><td align="center">Mean</td><td align="center">90% CI</td><td align="center">Bioequivalence <br/>limit</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">Ratio of <svg height="15.65" id="M70" style="vertical-align:-3.3907pt" version="1.1" viewbox="0 0 56.1875 15.65" width="56.1875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></td><td align="center">1.08</td><td align="center">1.02–1.14</td><td align="center">0.80–1.25</td></tr><tr><td align="left">Ratio of <svg height="15.6875" id="M71" style="vertical-align:-3.3907pt" version="1.1" viewbox="0 0 37.287498 15.6875" width="37.287498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></td><td align="center">1.08</td><td align="center">0.99–1.17</td><td align="center">0.80–1.25</td></tr><tr><td align="left">Difference in <svg height="15.8375" id="M72" style="vertical-align:-3.3907pt" version="1.1" viewbox="0 0 36.625 15.8375" width="36.625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg></td><td align="center">0.05</td><td align="center">(−0.19)–0.29</td><td align="center">±0.41</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

The mean and 90% confidence intervals (CI) of pharmacokinetic parameters of the test product (Tonizep) compared to the reference product (Aricept).

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tab2

Table 2

Table 2: Bioequivalence Study of Donepezil Hydrochloride Tablets in Healthy Male Volunteers 