Table of Contents
ISRN Pulmonology
Volume 2012, Article ID 534290, 8 pages
Clinical Study

Effect of Salt-Bromide-Iodine Thermal Water Inhalation on Functional and Biochemical Lung Parameters

1Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Via Gramsci 14, 43126 Parma, Italy
2Italian Workers' Compensation Authority (INAIL), Research Center at the University of Parma, Via Gramsci 14, 43126 Parma, Italy
3Department of Public Health, Faculty of Health Care and Social Work, Trnava University, 917 00 Trnava, Slovakia
4Terme of Monticelli, Via alle Terme, 43022 Monticelli Terme, Parma, Italy
5Laboratory of Industrial Hygiene and Toxicology, University Hospital of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy

Received 10 April 2012; Accepted 10 May 2012

Academic Editors: B. Antus and A. Miyazato

Copyright © 2012 Massimo Corradi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Inhalation of thermal water has been used empirically in the treatment of chronic diseases of upper and lower respiratory tract. This study investigates biomarkers of effect in exhaled breath (nitric oxide (NO)) and in exhaled breath condensate (EBC) (hydrogen peroxide ( H 2 O 2 ), anions, toxic heavy metals of tobacco smoke) for patients with lung diseases inhaling salt-bromide-iodine thermal water. Methods. This study enrolled two groups of patients, twenty with alveolar pulmonary diseases—pneumoconiosis—twenty-two with bronchial diseases. Patients received 12 days inhalation treatment with thermal water in Terme of Monticelli (Parma), Italy. Results. No statistically significant differences were found for NO at different flow rates in both groups of patients before and after thermal water inhalation. Also in EBC no statistically significant differences were present for H 2 O 2 concentrations, toxic heavy metals concentrations, and anion concentrations before and after treatment. Nitrates in EBC were found to be significantly higher in patients before inhalation than in controls as well as in patients after inhalation versus controls. Conclusions. This study contributes to better quantify functional and biochemical changes in airways before and after thermal water treatment.