Effect of Salt-Bromide-Iodine Thermal Water Inhalation on Functional and Biochemical Lung Parameters

Table 4

Effect of 12 days treatment with salt-bromide-iodine thermal water on flow-dependent NO parameters (FENO₅₀, FENO₁₀₀, FENO₁₅₀, FENO₃₅₀, J′_aw,NO, C_A,NO).

Variable	Alveolar diseases			Bronchial diseases
	BT	AT	^#𝑃 value	BT	AT	^#𝑃 value
FENO50 (ppb)	25 (13.3–37.8)	26 (16.7–44.5)	ns	24 (17–52)	20 (17–31)	ns
FENO100 (ppb)	18 (14–28)	18.5 (12–22.8)	ns	17 (12.5–24)	16 (11–26)	ns
FENO150 (ppb)	12 (11.5–23.5)	11.5 (9.7–23.5)	ns	15.5 (10–22)	12.5 (10.5–18.5)	ns
FENO350 (ppb)	10 (6.5–10.5)	9 (5.5–12.8)	ns	ND	ND	ND
J′aw,NO (nL/min)	54.8 (35.7–112)	65 (37.8–92.2)	ns	54.4 (35.8–80.6)	33.5 (24.0–73.8)	ns
CA,NO (ppb)	6.6 (3.1–12.2)	6.2 (4–9.6)	ns	7.4 (3.4–19.6)	9.4 (5–15.6)	ns

Data expressed as median IQR; IQR: interquartile range; ^#Wilcoxon rank-sum test; BT: before treatment; AT: after treatment; FENO₅₀: fractional nitric oxide concentration at flow rate of 50 mL/s; FENO₁₀₀: fractional nitric oxide concentration at flow rate of 100 mL/s; FENO₁₅₀: fractional nitric oxide concentration at flow rate of 150 mL/s; FENO₃₅₀: fractional nitric oxide concentration at flow rate of 350 mL/s; J′_aw,NO: maximum total airway nitric oxide flux; C_A,NO: alveolar nitric oxide concentration; ND: not determined; ns: not significant.