Table of Contents
ISRN Endocrinology
Volume 2012, Article ID 536905, 11 pages
http://dx.doi.org/10.5402/2012/536905
Review Article

Recent Advances in Obesity: Genetics and Beyond

1Division of Pediatric Nephrology, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
2Division of Neuroscience, Oregon National Primate Research Center, Department of Public Health & Preventive Medicine, Oregon Health & Science University, Portland, OR 97239, USA

Received 11 November 2011; Accepted 19 December 2011

Academic Editors: C. Anderwald, A. Hishinuma, and J.-F. Tanti

Copyright © 2012 Wai W. Cheung and Peizhong Mao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [37 citations]

The following is the list of published articles that have cited the current article.

  • Chandrashekhar V Apte, “Biological clocks: The coming of age.,” International journal of applied & basic medical research, vol. 2, no. 1, pp. 1–2, 2012. View at Publisher · View at Google Scholar
  • Peizhong Mao, “Recent progress and concerns in dementia: Distinguishing Alzheimer's disease and dementia with Lewy bodies via biochemical markers in the cerebrospinal fluid,” Advances in Biological Chemistry, vol. 02, no. 02, pp. 176–190, 2012. View at Publisher · View at Google Scholar
  • Carla Sustek D'Angelo, and Celia Priszkulnik Koiffmann, “Copy Number Variants in Obesity-Related Syndromes: Review and Perspectives on Novel Molecular Approaches,” Journal of Obesity, vol. 2012, pp. 1–15, 2012. View at Publisher · View at Google Scholar
  • Xi Zhou, YanLan Chai, Ke Chen, YunYi Yang, and Zi Liu, “A Meta-Analysis of Reference Values of Leptin Concentration in Healthy Postmenopausal Women,” PLoS ONE, vol. 8, no. 8, pp. e72734, 2013. View at Publisher · View at Google Scholar
  • Susan L. McElroy, Scott Crow, Joanna M. Biernacka, Stacey Winham, Jennifer Geske, Alfredo B. Cuellar Barboza, Miguel L. Prieto, Mohit Chauhan, Lisa R. Seymour, Nicole Mori, and Mark A. Frye, “Clinical phenotype of bipolar disorder with comorbid binge eating disorder,” Journal of Affective Disorders, 2013. View at Publisher · View at Google Scholar
  • John P Cello, and Stanley J Rogers, “Morbid obesity-the new pandemic: medical and surgical management, and implications for the practicing gastroenterologist.,” Clinical and translational gastroenterology, vol. 4, 2013. View at Publisher · View at Google Scholar
  • Eira Viikari-Juntura, “The obesity epidemic in the occupational health context,” Scandinavian Journal of Work Environment & Health, vol. 39, no. 3, pp. 217–219, 2013. View at Publisher · View at Google Scholar
  • Petra Suchankova, Elisabet Jerlhag, Nitya Jayaram-Lindstrom, Staffan Nilsson, Kjell Toren, Annika Rosengren, Jorgen A. Engel, and Johan Franck, “Genetic Variation of the Ghrelin Signalling System in Individuals with Amph etamine Dependence,” Plos One, vol. 8, no. 4, 2013. View at Publisher · View at Google Scholar
  • Sudha P. Pandalai, Paul A. Schulte, and Diane B. Miller, “Conceptual heuristic models of the interrelationships between obesity and the occupational environment,” Scandinavian Journal of Work, Environment and Health, vol. 39, no. 3, pp. 221–232, 2013. View at Publisher · View at Google Scholar
  • D. Reese McKay, Anderson M. Winkler, Rene L. Olvera, Melanie A. Carless, Thomas D. Dyer, Jack W. Kent, Peter Kochunov, Emma Sprooten, Emma E. Knowles, Anthony G. Comuzzie, Peter T. Fox, Laura Almasy, Ravindranath Duggirala, John Blangero, and David C. Glahn, “Identification of Pleiotropic Genetic Effects on Obesity and Brain Anatomy,” Human Heredity, vol. 75, no. 2-4, pp. 136–143, 2013. View at Publisher · View at Google Scholar
  • Ozhan Yalcin, Elvan Iseri, Neslihan Bukan, and Ugur Ercin, “Effects of Long Acting Methylphenidate on Ghrelin Levels in Male Children with Attention Deficit Hyperactivity Disorder: An Open Label Trial,” Klinik Psikofarmakoloji Bulteni-Bulletin of Clinical Psychopharmacology, vol. 24, no. 2, pp. 146–157, 2014. View at Publisher · View at Google Scholar
  • Hassan Rooki, Mohamad-Amin Pourhosseingholi, Mahmoud-Reza Azarpazhooh, Mahmoud Ebrahimi, Gordon Ferns, and Mohammad-Reza Zali, “Association of LXR alpha polymorphisms with obesity and obesity-related phenotypes in an Iranian population,” Annals of Human Biology, vol. 41, no. 3, pp. 214–219, 2014. View at Publisher · View at Google Scholar
  • Maria Pastor-Valero, Renata Furlan-Viebig, Paulo Rossi Menezes, Simon Almeida da Silva, Homero Vallada, and Marcia Scazufca, “Education and WHO Recommendations for Fruit and Vegetable Intake Are Associated with Better Cognitive Function in a Disadvantaged Brazilian Elderly Population: A Population-Based Cross-Sectional Study,” Plos One, vol. 9, no. 4, 2014. View at Publisher · View at Google Scholar
  • Nabilah I. Chowdhury, Renan P. Souza, Arun K. Tiwari, Eva J. Brandl, Michelle Sicard, Herbert Y. Meltzer, Jeffrey A. Lieberman, James L. Kennedy, and Daniel J. Müller, “Investigation of melanocortin system gene variants in antipsychotic-induced weight gain,” The World Journal of Biological Psychiatry, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Rakesh Bhasker, and Banalata Mohanty, “Pesticides in mixture disrupt metabolic regulation: In Silico and In Vivo analysis of cumulative toxicity of Mancozeb and Imidacloprid on body weight of mice,” General and Comparative Endocrinology, 2014. View at Publisher · View at Google Scholar
  • Nishikant K. Subhedar, Kartik T. Nakhate, Manoj A. Upadhya, and Dadasaheb M. Kokare, “CART in the brain of vertebrates: circuits, functions and evolution,” Peptides, 2014. View at Publisher · View at Google Scholar
  • Adrian Baez-Ruiz, Dalia Luna-Moreno, Agustin Carmona-Castro, Rene Cardenas-Vazquez, Mauricio Diaz-Munoz, Vania Carmona-Alcocer, Citlalli Fuentes-Granados, and Miranda-Anaya Manuel, “Hypothalamic expression of anorexigenic and orexigenic hormone receptors in obese females Neotomodon alstoni: Effect of fasting,” Nutritional Neuroscience, vol. 17, no. 1, pp. 31–36, 2014. View at Publisher · View at Google Scholar
  • N.A. Shabana, and Shahida Hasnain, “Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects,” Nutrition, vol. 31, no. 9, pp. 1136–1140, 2015. View at Publisher · View at Google Scholar
  • Shabana, Saleem Ullah Shahid, Ka Wah Li, Jayshree Acharya, Jackie A Cooper, Shahida Hasnain, and Stephen E Humphries, “Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects,” European Journal of Human Genetics, 2015. View at Publisher · View at Google Scholar
  • Shabana, and Shahida Hasnain, “The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis,” Gene, 2015. View at Publisher · View at Google Scholar
  • Angela Moreira, Sofia S. Pereira, Madalena Costa, Tiago Morais, Ana Pinto, Ruben Fernandes, and Mariana P. Monteiro, “Adipocyte Secreted Factors Enhance Aggressiveness of Prostate Carcinoma Cells,” Plos One, vol. 10, no. 4, 2015. View at Publisher · View at Google Scholar
  • Laura Kelly Vaughan, Howard W. Wiener, Stella Aslibekyan, David B. Allison, Peter J. Havel, Kimber L. Stanhope, Diane M. O’Brien, Scarlett E. Hopkins, Dominick J. Lemas, Bert B. Boyer, and Hemant K. Tiwari, “Linkage and association analysis of obesity traits reveals novel loci and interactions with dietary n-3 fatty acids in an Alaska Native (Yup’ik) population,” Metabolism, 2015. View at Publisher · View at Google Scholar
  • Yuriy Nozhenko, Madhu Asnani-Kishnani, Ana M. Rodríguez, and Andreu Palou, “Milk Leptin Surge and Biological Rhythms of Leptin and Other Regulatory Proteins in Breastmilk,” Plos One, vol. 10, no. 12, pp. e0145376, 2015. View at Publisher · View at Google Scholar
  • Shabana, and Shahida Hasnain, “Obesity, More than a ‘Cosmetic’ Problem. Current Knowledge and Future Prospects of Human Obesity Genetics,” Biochemical Genetics, 2015. View at Publisher · View at Google Scholar
  • Patricia Martins Bock, Mauricio Krause, Helena Trevisan Schroeder, Gabriela Fernandes Hahn, Hilton Kenji Takahashi, Cinthia Maria Schöler, Graziella Nicoletti, Luiz Domingos Zavarize Neto, Maria Inês Lavina Rodrigues, Maciel Alencar Bruxel, and Paulo Ivo Homem de Bittencourt, “Oral supplementations with l-glutamine or l-alanyl-l-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance,” Molecular and Cellular Biochemistry, vol. 411, no. 1-2, pp. 351–362, 2015. View at Publisher · View at Google Scholar
  • Murray Logan, Maria-Teresa Van der Merwe, Tyren M. Dodgen, Renier Myburgh, Arinda Eloff, Marco Alessandrini, and Michael S. Pepper, “ Allelic variants of the Melanocortin 4 receptor ( MC4R ) gene in a South African study group ,” Molecular Genetics & Genomic Medicine, 2015. View at Publisher · View at Google Scholar
  • Merlin G. Butler, Austen McGuire, and Ann M. Manzardo, “Clinically relevant known and candidate genes for obesity and their overlap with human infertility and reproduction,” Journal of Assisted Reproduction and Genetics, vol. 32, no. 4, pp. 495–508, 2015. View at Publisher · View at Google Scholar
  • Shabana, and Shahida Hasnain, “Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study,” BioMed Research International, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Sarah Anwar Qureshi, Amir Mumtaz, Saleem Ullah Shahid, and N.A. Shabana, “rs3751812, a common variant in fat mass and obesity-associated (FTO) gene, is associated with serum high- and low-density lipoprotein cholesterol in Pakistani individuals,” Nutrition, 2016. View at Publisher · View at Google Scholar
  • Tenzin Nyima, Michael Müller, Guido J. E. J. Hooiveld, Melissa J. Morine, and Marco Scotti, “Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice,” BMC Genomics, vol. 17, no. 1, 2016. View at Publisher · View at Google Scholar
  • Mahsa Jalili, Zahra Bazi, and Azita Hekmatdoost, “A novel treatment for weight reduction by the recombinant “Pichia pastoris” yeast expressing the hybrid protein of “irisin-furin-transferrin”,” Journal of Integrative Medicine, vol. 14, no. 1, pp. 1–4, 2016. View at Publisher · View at Google Scholar
  • Kim Lichtveld, Kent Thomas, and Nicolle S Tulve, “Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review,” Journal of Exposure Science and Environmental Epidemiology, 2017. View at Publisher · View at Google Scholar
  • Mohanraj Krishnan, Andrew N. Shelling, Clare R. Wall, Edwin A. Mitchell, Rinki Murphy, Lesley M.E. McCowan, and John M.D. Thompson, “Gene-by-environment interactions of the CLOCK , PEMT , and GHRELIN  loci with average sleep duration in relation to obesity traits using a cohort of 643 New Zealand European children,” Sleep Medicine, vol. 37, pp. 19–26, 2017. View at Publisher · View at Google Scholar
  • Olusegun E. Ogundele, Khalid O. Adekoya, Abraham A.A. Osinubi, Awoyemi A. Awofala, and Bola O. Oboh, “Association of adiponectin gene ( ADIPOQ ) polymorphisms with measures of obesity in Nigerian young adults,” Egyptian Journal of Medical Human Genetics, 2017. View at Publisher · View at Google Scholar
  • Elizabeth C. Prom-Wormley, Jane Ebejer, Danielle M. Dick, and M. Scott Bowers, “The genetic epidemiology of substance use disorder: A review,” Drug and Alcohol Dependence, vol. 180, pp. 241–259, 2017. View at Publisher · View at Google Scholar
  • Ravi Kasiappan, and Dheeran Rajarajan, “Role of MicroRNA Regulation in Obesity-Associated Breast Cancer: Nutritional Perspectives.,” Advances in nutrition (Bethesda, Md.), vol. 8, no. 6, pp. 868–888, 2017. View at Publisher · View at Google Scholar
  • Li Liu, Qianrui Fan, Feng Zhang, Xiong Guo, Xiao Liang, Yanan Du, Ping Li, Yan Wen, Jingcan Hao, Wenyu Wang, and Awen He, “A Genomewide Integrative Analysis of GWAS and eQTLs Data Identifies Multiple Genes and Gene Sets Associated with Obesity,” BioMed Research International, vol. 2018, pp. 1–5, 2018. View at Publisher · View at Google Scholar