Review Article
Recent Advances in Obesity: Genetics and Beyond
Table 1
Overview of main obesity-susceptibility loci identified through candidate gene and genome-wide association studies.
| Chromosomal location | Gene symbol | Gene name |
| 1p31.1 | NEGR1 | Neuronal growth regulator 1 | 1q41 | LYPLA1 | Lysophospholipase-like 1 | 1q25.2 | SEC16B | SEC 16 homologue B | | RASAL2 | RAS protein activator like 2 | 2p25.3 | TMEN18 | Transmembrane protein 18 | 2q14.1 | INSIG2 | Insulin-induced gene 2 | 3q27 | ETV5 | Ets variant gene 5 | 4p13 | GNPDA2 | Glucosamine-6-phosphate deaminase 2 | 5q13.3 | CART | Cocaine-and amphetamine-regulated transcript | 5q15-q21 | PCSK1 | Prohormone convertase 1/3 | 6p12 | TFAP2B | Transcription factor AP-2β | 6p22.2-p21.3 | PRL | Prolactin | 6q14-q15 | CNR1 | Endocannabinoid receptor 1 | 8p12-p11.2 | ADRB3 | Adrenergic β3 receptor | 8p23.1 | MSRA | Methionine sulfoxide reductase A | 10p12 | PTER | Phosphotriesterase related | 11p11.2 | MTCH2 | Mitochondrial carrier homologue 2 | 11p13 | BDNF | Brain-derived neurotrophic factor | 12q13 | BCDIN3D | BCDIN3-domain-containing | | FAIM2 | FAS apoptotic inhibitory molecule 2 | 14q31 | NRXN3 | Neurexin 3 | 16p11.2 | SH2B1 | SH2B adaptor protein 1 | | ATP2A1 | ATPase, Ca2+ transporting, cardiac muscle, fast twitch 1 | 16q12.2 | FTO | Fat mass and obesity-associated gene | 16q22-q23 | MAF v | Maf musculoaponeurotic fibrosarcoma oncogene homologue | 18q11-q12 | NPC1 | Niemann-Pick disease, type C1 | 18q22 | MC4R | Melanocortin 4 receptor | 19q13.11 | KCTD15 | Potassium channel tetramerisation domain containing 15 | 19q31 | CHST8 | Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | Xq23-24 | SLC6A14 | Solute carrier family 6 member 14 | | CUL4B | Cullin 4B |
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