Table 1: Overview of main obesity-susceptibility loci identified through candidate gene and genome-wide association studies.

Chromosomal locationGene symbolGene name

1p31.1NEGR1Neuronal growth regulator 1
1q41LYPLA1Lysophospholipase-like 1
1q25.2SEC16BSEC 16 homologue B
RASAL2RAS protein activator like 2
2p25.3TMEN18Transmembrane protein 18
2q14.1INSIG2Insulin-induced gene 2
3q27ETV5Ets variant gene 5
4p13GNPDA2Glucosamine-6-phosphate deaminase 2
5q13.3CARTCocaine-and amphetamine-regulated transcript
5q15-q21PCSK1Prohormone convertase 1/3
6p12TFAP2BTranscription factor AP-2β
6p22.2-p21.3PRLProlactin
6q14-q15CNR1Endocannabinoid receptor 1
8p12-p11.2ADRB3Adrenergic β3 receptor
8p23.1MSRAMethionine sulfoxide reductase A
10p12PTERPhosphotriesterase related
11p11.2MTCH2Mitochondrial carrier homologue 2
11p13BDNFBrain-derived neurotrophic factor
12q13BCDIN3DBCDIN3-domain-containing
FAIM2FAS apoptotic inhibitory molecule 2
14q31NRXN3Neurexin 3
16p11.2SH2B1SH2B adaptor protein 1
ATP2A1ATPase, Ca2+ transporting, cardiac muscle, fast twitch 1
16q12.2FTOFat mass and obesity-associated gene
16q22-q23MAF vMaf musculoaponeurotic fibrosarcoma oncogene homologue
18q11-q12NPC1Niemann-Pick disease, type C1
18q22MC4RMelanocortin 4 receptor
19q13.11KCTD15Potassium channel tetramerisation domain containing 15
19q31CHST8Carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
Xq23-24SLC6A14Solute carrier family 6 member 14
CUL4BCullin 4B