Nonlinear Dependence in the Discovery of Differentially Expressed Genes

Figure 3

Estimated conditional distributions of the number of false discoveries 𝑝(̂𝔉∣𝐶). Panel (a) BRCA data. Panel (b) HIV data. To show the effect of skewness corrections the third-moment 𝔉 distribution (solid curve) is compared to its second-moment counterpart (dashed curve). For BRCA the second-moment mean estimate is 79 compared to 104 for the third-moment, while for HIV these are 19 and 8. The BRCA curves are also labeled with 50% (solid line) and 75% (dotted line) confidence intervals.

(a)

(b)