Diagram illustrating internalization of the nanomedicine by the cell. In the incipient stage, the medicine invaginates the cell membrane to seek entry into the cell. Inside the cell, it is enveloped by plasma membrane forming the endosome. From the endosome, the medicine contents and target ligands are released, spreading into the cell. While the medicine cures the disease, the ligands migrate towards the cell surface to participate in drug targeting, thus commencing a fresh cycle of activity.
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