International Scholarly Research Notices / 2012 / Article / Tab 4

Review Article

Targeted Delivery of Nanomedicines

Table 4

Passive drug targeting scheme.

Sl. no.Stepwise formulation

(1)Studying the physiological conditions of diseased area
(2)Preparation of the delivery carrier having a definite molecular weight (>30 kDa), molecular size (100–200 nm), possessing hydrophilicity and neutral charge
(3)Adjusting the delivery system to be sensitive to pH, temperature, charge or an enzyme. The coating of the carrier is designed such that during circulation in blood, it is stable but when entering the capillaries in the tumor, where the temperature is slightly higher, the coating melts, and discharges the drug which accumulates in the tumor starting its action; such a carrier is said to be thermosensitive

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