Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 4

Forest plot (meta-analysis, random effect model) indicating the cumulative effect sizes for clinical attachment level gain at sites with moderate periodontitis (4–6 mm).

CAL gain at sites with moderate periodontitis (4–6 mm)						Std diff in means and 95% CI
Study	Antibiotic	Placebo	Std diff in means; 95% Cl	Z value	𝑃 value
Caton et al., 2000 [10]	90	93	0.244	1.647	0.100
Golub et al., 2001 [7]	27	39	0.807	3.103	0.002
Preshaw et al., 2004 [12]	10	10	0.039	0.280	0.78
Novak et al., 2002 [11]	107	102	0.775	1.672	0.094
Mohammad et al., 2005 [8]	66	76	0.53	3.096	0.002
Guerrero et al., 2005 [14]	20	21	0.615	1.925	0.054
Needleman et al., 2007 [16]	16	18	0.200	0.582	0.561
Synthesis	336	359	0.321	4.184	0.000

CAL: clinical attachment level, 𝑃<0.05, confidence level 95%.