Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

Table 6

Forest plot (meta-analysis, random effect model) indicating the cumulative effect sizes for clinical attachment level gain at sites with severe periodontitis (≥7 mm).

CAL gain at sites with severe periodontitis (≥7 mm)						Std diff in means and 95% CI
Study	Antibiotic	Placebo	Std diff in means; 95% Cl	Z value	𝑃 value
Caton et al., 2000 [10]	90	93	0.244	1.647	0.1
Preshaw et al., 2004 [12]	10	10	0.178	1.283	1.99
Novak et al., 2002 [11]	107	102	0.775	1.672	0.094
Mohammad et al., 2005 [8]	66	76	0.530	3.096	0.002
Guerrero et al., 2005 [14]	20	21	0.615	1.925	0.054
Needleman et al., 2007 [16]	16	18	0.200	0.582	0.561
Synthesis	309	320	0.322	4.004	0.000

CAL: clinical attachment level, 𝑃<0.05, confidence level 95%.