Research Article
Preparation of 99mTc-Clomiphene Citrate as a Novel Agent for Breast Cancer Imaging
Table 2
Biodistribution of
99mTc-Clomiphene in Swiss albino ascites bearing mice at different time intervals after injection.
| | Organs and body fluids | Percent ID/organ | | Time after injection | | 15 min | 30 min | 1 hr | 4 hr | 24 hr |
| | Blood | 16.5 ± 1.1 | 13.2 ± 0.6 | 8.4 ± 1.3 | 4.3 ± 1.3 | 1.5 ± 0.0 | | Kidneys | 19.1 ± 0.6 | 16.2 ± 2.5 | 15.4 ± 0.7 | 12.2 ± 1.2 | 3.2 ± 0.0 | | Liver | 3.7 ± 0.3 | 3.1 ± 0.6 | 2.2 ± 0.6 | 2.0 ± 0.5 | 1.8 ± 0.7 | | Spleen | 2.5 ± 0.1 | 2.7 ± 0.2 | 2.9 ± 0.1 | 2.9 ± 0.5 | 2.7 ± 0.3 | | Intestine | 4.6 ± 0.5 | 5.3 ± 0.6 | 6.7 ± 0.4 | 7.3 ± 1.1 | 7.8 ± 0.5 | | Stomach | 6.2 ± 0.3 | 8.4 ± 1.8 | 9.3 ± 0.8 | 11.6 ± 1.2 | 7.8 ± 0.5 | | Lungs | 7.5 ± 0.1 | 4.3 ± 0.5 | 2.6 ± 0.2 | 1.9 ± 0.3 | 1.4 ± 0.2 | | Heart | 8.0 ± 0.3 | 7.1 ± 1.2 | 2.2 ± 0.2 | 2.1 ± 0.9 | 1.5 ± 0.1 | | Thyroid | 0.5 ± 0.03 | 1.0 ± 0.5 | 1.4 ± 0.02 | 1.9 ± 0.6 | 1.2 ± 0.1 | | Muscle | 1.3 ± 0.1 | 1.9 ± 0.4 | 2.6 ± 0.2 | 3.9 ± 1.1 | 2.6 ± 0.3 | | Bone | 1.0 ± 0.1 | 1.2 ± 0.1 | 3.0 ± 0.1 | 2.2 ± 0.7 | 2.3 ± 0.3 | | Ascites | 3.30 ± 0.3 | 5.4 ± 1.2 | 12.6 ± 0.4 | 7.8 ± 0.8 | 4.6 ± 0.2 |
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% ID/gram ± S.D, n = 6.
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