| | No. | MMP | MMP class | Enzyme | Molecular weight (kDa) | Substrates |
| | 1 | MMP-1 | Collagenases | Collagenase-1 | 57*
47 A | Collagens (I, II, III, VII, and X), proteoglycans, entactin, ovostatin, MMP-2, MMP-9 | | 2 | MMP-8 | Collagenases | Collagenase-2/neutrophil collagenase | 85*
64 A | Collagens (I, II, III, VII, VIII, and X), fibronectin, proteoglycans | | 3 | MMP-13 | Collagenases | Collagenase-3 | 60*
48 A | Collagens (I, II, III, VII, VIII, and X), tenascin, plasminogen, aggrecan, fibronectin, osteonectin, MMP-9 | | 4 | MMP-18 | Collagenases | Collagenase-4 | 53*
51 A | Type I collagen | | 5 | MMP-2 | Gelatinases | Gelatinase-A | 72*
66 A | Gelatin, collagen (IV, V, VII VI, IX, and X), elastin, fibronectin | | 6 | MMP-9 | Gelatinases | Gelatinase-A | 92*
86 A | Collagens (IV, V, VII, X, and XIV), gelatin, entactin, elastin, fibronectin, osteonectin, plasminogen, proteoglycans | | 7 | MMP-3 | Stromelysins | Stromelysin-I | 60*
52 A | Collagens (IV, V, and IX), gelatin, aggrecan, laminin, elastin, casein, osteonectin, fibronectin, ovostatin, entactin, plasminogen | | 8 | MMP-10 | Stromelysins | Stromelysin-2 | 53*
47 A | Collagens (I, II, IV, and V), gelatin, casein, elastin, fibronectin | | 9 | MMP-11 | Stromelysins | Stromelysin-2 | 60*
47 A | Collagens (IV, V, IX, and X), laminin, elastin, fibronectin, casein, proteoglycans | | 10 | MMP-17 | Stromelysins | Homology tostromelysin-2 | 65*
63 A | Pro-MMP2, fibrin/fibrinogen, gelatin | | 11 | MMP-7 | Matrisylins | Matrisylin | 28*
19 A | Collagen IV, gelatin, fibronectin, laminin, elastin, casein, transferrin | | 12 | MMP-26 | Matrisylins | Matrisylin-2 | 29 | Collagen IV, fibronectin, fibrinogen, gelatin, pro-MMP9 | | 13 | MMP-14 | MT-MMP (membrane type-MMP) | MT1-MMP | 66*
54 A | Collagens (I, II, III), gelatin, fibronectin, laminin, vitronectin, entactin, pro-MMP-2 | | 14 | MMP-15 | MT-MMP | MT2-MMP | 76 | Fibronectin, gelatin, vitronectin, entactin, laminin, pro-MMP-2 | | 15 | MMP-16 | MT-MMP | MT3-MMP | 65*
63 A | Collagen III, gelatin, casein, fibronectin, pro-MMP-2 | | 16 | MMP-17 | MT-MMP | MT4-MMP | 65*
63 A | Pro-MMP-2, fibrinogen, gelatin | | 17 | MMP-24 | MT-MMP | MT5-MMP | 73 | Fibronectin, pro-MMP-2, proteoglycans, gelatin | | 18 | MMP-25 | MT-MMP | MT6-MMP | 62 | Pro-MMP-2, pro-MMP-9, collagen IV, gelatin, fibronectin, proteinase A | | 19 | MMP-12 | Other enzymes | Macrophage metalloelastase | 54*
45 A | Collagen IV, gelatin, elastin, casein, fibronectin, vitronectin, laminin, entactin, fibrin/fibrinogen | | 20 | MMP-19 | Other enzymes | RASI I | 59 | Collagen (I, IV) gelatin, fibronectin, laminin | | 21 | MMP-20 | Other enzymes | Enamelysin | 56 | Amelogenin, aggrecan | | 22 | MMP-21 | Other enzymes | | 65 | | | 23 | MMP-22 | Other enzymes | | 58*
53 A | | | 24 | MMP-23 | Other enzymes | | 44 | Gelatin | | 25 | MMP-27 | Other enzymes | | 59 | | | 26 | MMP-28 | Other enzymes | Epilysin | 59 | |
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