Computed Three-Dimensional Atlas of Subthalamic Nucleus and Its Adjacent Structures for Deep Brain Stimulation in Parkinson's Disease

Table 2

The chief complaints, clinical effects, and anatomical locations of the stimulated contacts in 11 patients treated with deep brain stimulation.

Case no.	UPDRS		Localization of stimulated contact		AC-PC (mm)	RN (mm)	Akinesia		Tremor				Gait disturbance		On-Off (%/day)		Dyskinesia (%/day)		Levodopa equivalent (mg/day)
			Right	Left					Right		Left
	Pre	Post					Pre	Post	Pre	Post	Pre	Post	Pre	Post	Pre	Post	Pre	Post	Pre	Post
1	19	10	ZI	ZI	22	4.8	4	0	0	0	0	0	2	1	50	20	70	30	565	468
2	26	9	FH	FH	22	6.0	5	0	0	0	0	0	4	2	20	20	70	30	347	280
3	28	16	ZI	FH	21	6.0	5	2	1	0	2	0	4	3	40	0	0	0	533	418
4	31	15	ZI	ZI	21	6.0	8	1	0	0	5	0	5	4	60	0	50	0	628	400
5	19	4	ZI	STN	20	6.0	2	1	2	0	4	0	2	0	0	0	0	0	342	271
6	28	12	STN	STN	23	4.0	3	1	3	1	3	0	5	3	0	0	0	0	396	253
7	44	25	ZI	STN	24	6.0	10	7	3	0	3	1	5	3	0	0	0	0	557	590
8	73	60	ZI	FH	25	5.4	10	7	2	0	2	0	10	10	70	50	50	20	503	503
9	24	7	STN	STN	21	5.6	1	0	3	0	2	0	4	3	30	0	50	20	570	500
10	44	16	FH	FH	21	6.0	6	2	3	0	3	0	4	3	0	0	70	20	285	285
11	13	4	ZI	No placement	24	5.0	1	0	0	0	5	0	1	0	0	0	0	0	440	307
Mean	31.7	16.5			22.2	5.5	5	1.9	1.5	0.1	2.6	0.1	4.2	2.9	24.5	8.2	32.7	10.9	470	388.6
± S.D.	16.7	15.6			1.6	0.7	3.3	2.6	1.4	0.3	1.7	0.3	2.4	2.7	27.0	16.0	32.3	13.0	113.5	116.1

Akinesia: UPDRS II items 9, 10, 11, 12, 13, 14, 15, on-off and percentage of daily time spent in off states, tremor: UPDRS III items 20 and 21, gait disturbance: UPDRS III items 27, 28, 29, and 30, dyskinesia: the percentage of daily time spent in dyskinesia, rigidity: UPDRS III item 22 on the side contralateral to DBS stimulation.
AC-PC: distance of anterior commissure-posterior commissure, RN: lateral distance from the midline of red nucleus, ZI: zona incerta, STN: subthalamic nucleus, FH: field of forel H, and mean ± S.D.: mean ± standard deviation, pre: before surgery, post: after surgery.