Models, Regulations, and Functions of Microtubule Severing by Katanin

Table 1

Katanin and other different AAA family microtubule severing proteins.

Protein	Species	Length*	Domains and length*	NCBI accession number
Katanin	Homo sapiens	p60–491; p80–655	p60-PRK04195 (209–265), AAA (241–382), Vps4_C (456–489),; p80-WD40 (7–257), Con80 (492–652)	p60: AAC25114; p80: NP_005877
Spastin	Homo sapiens	584	MIT (116–195),; AAA (313–476)	AAI50261
Fidgetin	Homo sapiens	759	AAA (519–654),; Vps4_C (707–756)	NP_060556
Lipotransin	Mus musculus	491	PRK04195 (211–265); AAA (241–382); Vps4_C (456–489)	AAD42087
Katanin-like 1 (KL1)	Homo sapiens	490	AAA (211–380); Vps4_C (447–488)	NP_001014402
Fidgetin-like 1	Homo sapiens	674	AAA (531–567); Vps4_C (631–671)	AAH51867
MSP1	Saccharomyces cerevisiae	362	VWA (10–164); AAA (123–257)	CAA97015
VPS4A	Homo sapiens	437	MIT_VPS4 (4–79); AAA (130–293); Vps4_C (373–434)	NP_037377

* All lengths are given in amino acid stretch length in the polypeptide/protein.
(Domain Abbreviations: PRK04195: replication factor C-large subunit, Vps4_C: Vps4 C-terminal oligomerization domain, WD40: beta transducin repeat of 40 aminoacids ending with Tryptophan and Aspartate, MIT: microtubule interacting and trafficking domain, AAA: ATPase associated with diverse cellular activities, VWA: von Willebrand factor type A domain).