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ISRN Psychiatry
Volume 2012 (2012), Article ID 596486, 8 pages
Clinical Study

Clozapine Augments Delta, Theta, and Right Frontal EEG Alpha Power in Schizophrenic Patients

1Department of Psychiatry, McMaster University, Hamilton, ON, Canada L8S 4L8
2St. Joseph's Mountain Healthcare Services, 100 West 5th Street, Hamilton, ON, Canada L8N 3K7
3Department of Medicine, Queen's University, Kingston, ON, Canada K7L 4Z4
4QEEG Assessment Services Inc., Thornhill, ON, Canada L3T 4Z4
5Department of Psychiatry, Queen's University, Kingston, ON, Canada K7L 4Z4

Received 11 January 2012; Accepted 30 January 2012

Academic Editors: C. M. Beasley and R. Yoshimura

Copyright © 2012 D. MacCrimmon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To explore the Quantitative EEG (QEEG) effects of established clozapine therapy regimes compared to those of previous ineffective antipsychotic regimes among 64 chronic (DSM-IV) schizophrenic patients. Methods. Data from 20 EEG channels referenced to linked ears were collected before and during maintenance clozapine therapy (mean duration 1.4 years). Absolute power was calculated in six frequency bands: delta (0.4–3.6 Hz), theta (4.2–7.8 Hz), alpha (8.2–11.8 Hz), beta1 (12.2–15.8 Hz), beta2 (16.2–19.8 Hz), and beta3 (20.2–23.8 Hz). Results. Clozapine augments power globally in the delta and theta bands, but this effect is more pronounced over frontal areas. Beta3 power was reduced. Alpha showed a frontal increase, more pronounced in the right, coupled with a posterior decrease with no net change in overall power. Conclusion. The demonstration of a significant clozapine-induced alpha topographic shift frontally and to the right is a novel discovery that may serve to encourage further investigations of subcortical structures in attempts to better understand the diverse aetiologies and optimal treatments of the schizophrenias.