Table of Contents
ISRN Dermatology
Volume 2012, Article ID 609158, 9 pages
Research Article

Possible Migration and Histopathological Analysis of Injections of Polymethylmethacrylate in Wistar Rats

1Department of Surgery, Federal University of Santa Catarina (UFSC), 88040-900 Florianópolis, SC, Brazil
2Plastic Surgery Service, University Hospital of the Federal University of Santa Catarina, 88040-900 Florianópolis, SC, Brazil
3General Surgery Program, Hospital Governador Celso Ramos, 88015-270 Florianópolis, SC, Brazil
4Institute of Pathological Anatomy Diagnositcs, Florianópolis, SC, Brazil

Received 25 January 2012; Accepted 16 February 2012

Academic Editors: C. Johansen and A. Zalewska

Copyright © 2012 Rodrigo d'Eça Neves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the possible migration of polymethylmethacrylate after injections in various corporal compartments of Wistar rats. Methods. The experimental work consisted in the injection of PMMA in corporal compartments for later histopathological analysis of the locations of implants and of distant filtering organs. The dose applied in each implant was of 0.2 mL. The animals were divided into groups according to the location of the implant realized: group GB had intradermic injections in the glabella. Group SD had subdermal injections in dorsal subcutaneous tissue cells. Group IP had intraperitoneal injections in the abdomen. Group PD had intramuscular injections in the right rear leg. The rats were sacrificed 30 days after realization of the implants and tissue samples from the lung, liver, spleen, and kidney, and locations of implantation were removed for histopathological analysis. Results. Characteristic microspheres that were compatible with the presence of PMMA in any of the histological slides analyzed were not observed. One animal had an amorphous exogenous substance, with a histiocytic reaction. Twelve of the 16 lungs analyzed had locations of intraalveolar hemorrhaging. Two animals had nonspecific spleen alterations. Conclusion. The histopathological analysis of this study found no PMMA microspheres in any of the tissues analyzed.