Review Article

Development of Safer Gene Delivery Systems to Minimize the Risk of Insertional Mutagenesis-Related Malignancies: A Critical Issue for the Field of Gene Therapy

Figure 3

This figure reports the second mechanism for cellular oncogene expression, which is caused by the long-range interaction of the retroviral enhancer and the endogenous promoter of the cellular oncogene. The blue block arrow represents the interaction between the retroviral enhancer and the endogenous promoter of the cellular oncogene.
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