International Scholarly Research Notices

Research Article

High-Fat Programming of Hyperglycemia, Hyperinsulinemia, Insulin Resistance, Hyperleptinemia, and Altered Islet Architecture in 3-Month-Old Wistar Rats

Table 2

Islet cell ratios, islet cell, and acinar cell proliferation in 3-month-old male and female rats.
 ControlHFGHFPHFGP
Beta-cell to alpha-cell ratio    
 Males 2 . 7 1 ± 0 . 4 2
𝑛 = 3 		2 . 7 0 ± 0 . 7 8
𝑛 = 3 		3 . 0 8 ± 0 . 2 0
𝑛 = 4 		5 . 0 7 ± 1 . 9 5
𝑛 = 3
 Females 3 . 9 4 ± 0 . 6 4
𝑛 = 5 		4 . 6 0 ± 0 . 5 4
𝑛 = 3 		3 . 3 6 ± 0 . 5 1
𝑛 = 3 		—
Alpha-cell to beta-cell ratio    
 Males 0 . 3 9 ± 0 . 0 7
𝑛 = 3 		0 . 4 8 ± 0 . 1 9
𝑛 = 3 		0 . 3 3 ± 0 . 0 2
𝑛 = 4 		0 . 2 6 ± 0 . 0 8
𝑛 = 3
 Females 0 . 2 8 ± 0 . 0 4
𝑛 = 5 		0 . 2 2 ± 0 . 0 2
𝑛 = 3 		0 . 3 1 ± 0 . 0 4
𝑛 = 3 		—
Islet cell proliferation    
 Males 0 . 0 0 2 3 ± 0 . 0 0 0 3
𝑛 = 3 		0 . 0 0 6 5 ± 0 . 0 0 0 5
𝑛 = 3 		0 . 0 1 2 5 ± 0 . 0 0 3 9
𝑛 = 4 		0 . 0 0 8 7 ± 0 . 0 0 0 5
𝑛 = 3
Acinar cell proliferation    
 Males 0 . 0 0 0 8 ± 0 . 0 0 0 1 2
𝑛 = 3 		0 . 0 0 1 7 ± 0 . 0 0 0 4
𝑛 = 3 		0 . 1 3 9 3 ± 0 . 0 3 8 7 ∗ † §
𝑛 = 4 		0 . 0 0 6 2 ± 0 . 0 0 1 4
𝑛 = 3
HFG: high-fat diet during fetal life; HFP: high-fat diet during postnatal life; HFGP: high-fat diet during both fetal and postnatal life. Data are means ± SEM. ∗ 𝑃 < 0 . 0 5 versus control; † 𝑃 < 0 . 0 5 versus HFG; § 𝑃 < 0 . 0 5 versus HFGP.