Table of Contents
ISRN Allergy
Volume 2012 (2012), Article ID 627545, 6 pages
http://dx.doi.org/10.5402/2012/627545
Research Article

Unscrambling Egg Allergy: The Diagnostic Value of Specific IgE Concentrations and Skin Prick Tests for Ovomucoid and Egg White in the Management of Children with Hen’s Egg Allergy

1Clinical Investigation Unit, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol BS2 8BJ, UK
2Paediatric Allergy, Immunology and Infectious Diseases, Southampton University Hospital NHS Trust, Tremona Road, Southampton SO16 6YD, UK
3Immunology Department, Southmead Hospital, Bristol BS10 5NB, UK
4School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK

Received 1 December 2011; Accepted 25 December 2011

Academic Editors: A. Horner and A. Kantar

Copyright © 2012 D. E. Marriage et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. H. Sicherer and H. A. Sampson, “Food allergy,” Journal of Allergy and Clinical Immunology, vol. 117, supplement 2, pp. S470–S475, 2006. View at Google Scholar
  2. M. Eggesbø, G. Botten, R. Halvorsen, and P. Magnus, “The prevalence of allergy to egg: a population-based study in young children,” Allergy, vol. 56, no. 5, pp. 403–411, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. S. H. Sicherer and H. A. Sampson, “Food allergy,” Journal of Allergy and Clinical Immunology, vol. 125, no. 2, Supplement 2, pp. S116–S125, 2010. View at Google Scholar
  4. T. Boyano-Martínez, C. García-Ara, J. M. Díaz-Pena, and M. Martín-Esteban, “Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy,” Journal of Allergy and Clinical Immunology, vol. 110, no. 2, pp. 304–309, 2002. View at Publisher · View at Google Scholar
  5. A. Dannaeus and M. Inganas, “A follow-up study of children with food allergy. Clinical course in relation to serum IgE- and IgG-antibody levels to milk, egg and fish,” Clinical Allergy, vol. 11, no. 6, pp. 533–539, 1981. View at Google Scholar · View at Scopus
  6. H. A. Sampson and C. C. McCaskill, “Food hypersensitivity and atopic dermatitis: evaluation of 113 patients,” Journal of Pediatrics, vol. 107, no. 5, pp. 669–675, 1985. View at Google Scholar · View at Scopus
  7. R. A. Wood, “The natural history of food allergy,” Pediatrics, vol. 111, no. 6, pp. 1631–1637, 2003. View at Google Scholar · View at Scopus
  8. J. H. Savage, E. C. Matsui, J. M. Skripak, and R. A. Wood, “The natural history of egg allergy,” Journal of Allergy and Clinical Immunology, vol. 120, no. 6, pp. 1413–1417, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Stoger and B. Wulhrich, “Type I allergy to cow milk proteins in adults. A retrospective study of 34 adult milk- and cheese-allergic patients,” International Archives of Allergy and Immunology, vol. 102, no. 4, pp. 399–407, 1993. View at Google Scholar · View at Scopus
  10. A. Urisu, H. Ando, Y. Morita et al., “Allergenic activity of heated and ovomucoid-depleted egg white,” Journal of Allergy and Clinical Immunology, vol. 100, no. 2, pp. 171–176, 1997. View at Publisher · View at Google Scholar · View at Scopus
  11. G. N. Konstantinou, S. Giavi, A. Kalobatsou et al., “Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: hypothesis-generating observations,” Journal of Allergy and Clinical Immunology, vol. 122, no. 2, pp. 414–415, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. P. A. Eigenmann, “Anaphylactic reactions to raw eggs after negative challenges with cooked eggs,” Journal of Allergy and Clinical Immunology, vol. 105, no. 3, pp. 587–588, 2000. View at Google Scholar · View at Scopus
  13. M. C. Garcia-Ara, M. T. Boyano-Martínez, J. M. Díaz-Pena, M. F. Martín-Muñoz, and M. Martin-Esteban, “Cow's milk-specific immunoglobulin E levels as predictors of clinical reactivity in the follow-up of the cow's milk allergy infants,” Clinical and Experimental Allergy, vol. 34, no. 6, pp. 866–870, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Ando, R. Movérare, Y. Kondo et al., “Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy,” Journal of Allergy and Clinical Immunology, vol. 122, no. 3, pp. 583–588, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. D. R. Hoffman, “Immunochemical identification of the allergens in egg white,” Journal of Allergy and Clinical Immunology, vol. 71, no. 5, pp. 481–486, 1983. View at Google Scholar · View at Scopus
  16. T. Langeland, “A clinical and immunological study of allergy to hen's egg white. III. Allergens in hen's egg white studied by crossed radio-immunoelectrophoresis (CRIE),” Allergy, vol. 37, no. 7, pp. 521–530, 1982. View at Google Scholar · View at Scopus
  17. E. Holen and S. Elsayed, “Characterization of four major allergens of hen egg-white by IEF/SDS-PAGE combined with electrophoretic transfer and IgE-immunoautoradiography,” International Archives of Allergy and Applied Immunology, vol. 91, no. 2, pp. 136–141, 1990. View at Google Scholar · View at Scopus
  18. S. K. Cooke and H. A. Sampson, “Allergenic properties of ovomucoid in man,” Journal of Immunology, vol. 159, no. 4, pp. 2026–2032, 1997. View at Google Scholar · View at Scopus
  19. A. Nowak-Wgrzyn and H. A. Sampson, “Future therapies for food allergies,” Journal of Allergy and Clinical Immunology, vol. 127, no. 3, pp. 558–573, 2011. View at Publisher · View at Google Scholar
  20. K. M. Järvinen, K. Beyer, L. Vila, L. Bardina, M. Mishoe, and H. A. Sampson, “Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy,” Allergy, vol. 62, no. 7, pp. 758–765, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. T. J. Fagan, “Letter: nomogram for Bayes theorem,” New England Journal of Medicine, vol. 293, no. 5, p. 257, 1975. View at Google Scholar · View at Scopus
  22. H. A. Sampson and D. G. Ho, “Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents,” Journal of Allergy and Clinical Immunology, vol. 100, no. 4, pp. 444–451, 1997. View at Publisher · View at Google Scholar · View at Scopus
  23. A. H. Benhamou, J. C. Caubet, P. A. Eigenmann et al., “State of the art and new horizons in the diagnosis and management of egg allergy,” Allergy, vol. 65, no. 3, pp. 283–289, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Boyano Martínez, C. García-Ara, J. M. Díaz-Pena, F. M. Muñoz, G. García Sánchez, and M. M. Esteban, “Validity of specific IgE antibodies in children with egg allergy,” Clinical and Experimental Allergy, vol. 31, no. 9, pp. 1464–1469, 2001. View at Publisher · View at Google Scholar
  25. S. Celik-Bilgili, A. Mehl, A. Verstege et al., “The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges,” Clinical and Experimental Allergy, vol. 35, no. 3, pp. 268–273, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Komata, L. Söderström, M. P. Borres, H. Tachimoto, and M. Ebisawa, “The predictive relationship of food-specific serum IgE concentrations to challenge outcomes for egg and milk varies by patient age,” Journal of Allergy and Clinical Immunology, vol. 119, no. 5, pp. 1272–1274, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Osterballe and C. Bindslev-Jensen, “Threshold levels in food challenge and specific Ige in patients with egg allergy: is there a relationship?” Journal of Allergy and Clinical Immunology, vol. 112, no. 1, pp. 196–201, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Lemon-Mulé, H. A. Sampson, S. H. Sicherer, W. G. Shreffler, S. Noone, and A. Nowak-Wegrzyn, “Immunologic changes in children with egg allergy ingesting extensively heated egg,” Journal of Allergy and Clinical Immunology, vol. 122, no. 5, pp. 977–983.e1, 2008. View at Publisher · View at Google Scholar · View at Scopus