Table of Contents
ISRN Gastroenterology
Volume 2012 (2012), Article ID 628317, 9 pages
http://dx.doi.org/10.5402/2012/628317
Review Article

What Really Causes Necrotising Enterocolitis?

General Medicine, King’s College Hospital, London SE5 9RS, UK

Received 11 October 2012; Accepted 19 November 2012

Academic Editors: A. Nakajima and W. Vogel

Copyright © 2012 Thomas Peter Fox and Charles Godavitarne. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. L. Grosfeld, “Jejumoilial atresia and stenosis,” in Paediatric Surgery, p. 838, Chicago, Ill, USA, 4th edition, 1986. View at Google Scholar
  2. L. W. Martin and J. T. Zerella, “Jejunoilial atresia: a proposed classification,” Journal of Pediatric Surgery, vol. 11, p. 1149, 1967. View at Google Scholar
  3. N. McIntosh, P. Helms, S. Rosalind, and S. Logan, Textbook of Paediatrics, Churchill Livingston, London, UK, 7th edition, 2008.
  4. P. W. Wales and E. R. Christison-Lagay, “Short bowel syndrome: epidemiology and etiology,” Seminars in Pediatric Surgery, vol. 19, no. 1, pp. 3–9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. B. P. Modi, M. Langer, Y. A. Ching et al., “Improved survival in a multidisciplinary short bowel syndrome program,” Journal of Pediatric Surgery, vol. 43, no. 1, pp. 20–24, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. D. A. Kafetzis, C. Skevaki, and C. Costalos, “Neonatal necrotizing enterocolitis: an overview,” Current Opinion in Infectious Diseases, vol. 16, no. 4, pp. 349–355, 2003. View at Google Scholar · View at Scopus
  7. A. Paltauf, “Die spontane dickdarmruptur der neugebornen,” Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin, vol. 111, no. 3, pp. 461–474, 1888. View at Publisher · View at Google Scholar · View at Scopus
  8. O. Schmid and K. Quaiser, “Uer eine besondere schwere verlaufende Form von Enteritis beim saugling,” Oesterr Z Kinderh, vol. 8, p. 114, 1953. View at Google Scholar
  9. A. M. Kosloske, “Epidemiology of necrotizing enterocolitis,” Acta Paediatrica, Supplement, vol. 83, no. 396, pp. 2–7, 1994. View at Google Scholar · View at Scopus
  10. R. C. Holman, B. J. Stoll, M. J. Clarke, and R. I. Glass, “The epidemiology of necrotizing enterocolitis infant mortality in the United States,” American Journal of Public Health, vol. 87, no. 12, pp. 2026–2031, 1997. View at Google Scholar · View at Scopus
  11. R. D. Uauy, A. A. Fanaroff, S. B. Korones, E. A. Phillips, J. B. Philips, and L. L. Wright, “Necrotizing entercolitis in very low birth weight infants: biodemographic and clinical correlates,” Journal of Pediatrics, vol. 119, no. 4, pp. 630–638, 1991. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Rennie, Roberton’s Textbook of Neonatology, Elsevier, Beijing, China, 4th edition, 2005.
  13. A. M. Kosloske, “Epidemiology of necrotising enterocolitis,” Acta Paediatrica, vol. 83, no. s396, pp. 2–7, 1994. View at Publisher · View at Google Scholar
  14. A. Lucas and R. Abbott, “British paediatric surveillance unit,” Annual Report, Royal College of Paediatrics and Child Health, 1997, http://bpsu.inopsu.com/publications/reports/nnec.html. View at Google Scholar
  15. P. J. Beeby and H. Jeffery, “Risk factors for necrotising enterocolitis: the influence of gestational age,” Archives of Disease in Childhood, vol. 67, no. 4, pp. 432–435, 1992. View at Google Scholar · View at Scopus
  16. D. A. Clark and M. Miller, “What causes NEC and how can it be prevented? Current topics,” in Neonatology 1, pp. 160–176, Saunders, London, UK, 1996. View at Google Scholar
  17. R. M. Kliegman, W. A. Walker, and R. H. Yolken, “Necrotizing enterocolitis: research agenda for a disease of unknown etiology and pathogenesis,” Pediatric Research, vol. 34, no. 6, pp. 701–708, 1993. View at Google Scholar · View at Scopus
  18. T. V. Santulli, J. N. Schullinger, and W. C. Heird, “Acute necrotizing enterocolitis in infancy: a review of 64 cases,” Pediatrics, vol. 55, no. 3, pp. 376–387, 1975. View at Google Scholar · View at Scopus
  19. R. Engel, N. Virnig, C. Hunt, and M. Levitt, “Origin of mural gas in NEC,” Paediatric Research, vol. 7, p. 292, 1975. View at Google Scholar
  20. G. B. Hopkins, V. E. Gould, J. K. Stevenson, and T. K. Oliver Jr., “Necrotizing enterocolitis in premature infants. A clinical and pathologic evaluation of autopsy material,” American Journal of Diseases of Children, vol. 120, no. 3, pp. 229–232, 1970. View at Google Scholar
  21. J. A. Morecroft, L. Spitz, P. A. Hamilton, and S. J. K. Holmes, “Plasma interleukin-6 and tumour necrosis factor levels as predictors of disease severity and outcome in necrotizing enterocolitis,” Journal of Pediatric Surgery, vol. 29, no. 6, pp. 798–800, 1994. View at Publisher · View at Google Scholar · View at Scopus
  22. A. K. Ewer, “Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis,” Acta Paediatrica. Supplement, vol. 91, no. 437, pp. 2–5, 2002. View at Google Scholar
  23. W. MacKendrick, N. Hill, W. Hsueh, and M. Caplan, “Increase in plasma platelet-activating factor levels in enterally fed preterm infants,” Biology of the Neonate, vol. 64, no. 2-3, pp. 89–95, 1993. View at Google Scholar · View at Scopus
  24. M. S. Caplan, E. Hedlund, L. Adler, M. Lickerman, and W. Hsueh, “The platelet-activating factor receptor antogonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats,” Journal of Pediatric Gastroenterology and Nutrition, vol. 24, no. 3, pp. 296–301, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. M. D. Amer, E. Hedlund, J. Rochester, and M. S. Caplan, “Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis,” Biology of the Neonate, vol. 85, no. 3, pp. 159–166, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Rennie, Roberton’s Textbook of Neonatology, Elsevier, Beijing, China, 4th edition, 2005.
  27. I. R. Holzman and D. R. Brown, “Necrotizing enterocolitis: a complication of prematurity,” Seminars in Perinatology, vol. 10, no. 3, pp. 208–216, 1986. View at Google Scholar · View at Scopus
  28. D. A. Clark and M. J. S. Miller, “What causes neonatal necrotising enterocolitis and how can it be prevented? Current topics,” in Neonatology 1, pp. 160–176, WB Saunders, London, UK, 1996. View at Google Scholar
  29. V. Y. H. Yu, R. Joseph, and B. Bajuk, “Perinatal risk factors for necrotizing enterocolitis,” Archives of Disease in Childhood, vol. 59, no. 5, pp. 430–434, 1984. View at Google Scholar · View at Scopus
  30. A. Bajraktarevic, A. D. Djulepa, H. Boloban et al., “Low birth weight is the most important risk factor for developing necrotizing enterocolitis in Bosnia,” Early Human Development, vol. 86, p. S71, 2010. View at Google Scholar
  31. P. J. Beeby and H. Jeffery, “Risk factors for necrotising enterocolitis: the influence of gestational age,” Archives of Disease in Childhood, vol. 67, no. 4, pp. 432–435, 1992. View at Google Scholar · View at Scopus
  32. J. Rennie, Roberton’s Textbook of Neonatology, Elsevier, Beijing, China, 4th edition, 2005.
  33. B. M. Carter and D. Holditch-Davis, “Risk factors for necrotizing enterocolitis in preterm infants: how race, gender, and health status contribute,” Advances in Neonatal Care, vol. 8, no. 5, pp. 285–290, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. D. E. Ballot, T. F. Chirwa, and P. A. Cooper, “Determinants of survival in very low birth weight neonates in a public sector hospital in Johannesburg,” BMC Pediatrics, vol. 10, article no. 30, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. A. R. Llanos, M. E. Moss, M. C. Pinzòn, T. Dye, R. A. Sinkin, and J. W. Kendig, “Epidemiology of neonatal necrotising enterocolitis: a population-based study,” Paediatric and Perinatal Epidemiology, vol. 16, no. 4, pp. 342–349, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. S. R. Palmer, S. J. Thomas, R. W. I. Cooke et al., “Birthweight-specific risk factors for necrotising enterocolitis,” Journal of Epidemiology and Community Health, vol. 41, no. 3, pp. 210–214, 1987. View at Google Scholar · View at Scopus
  37. G. A. Hackett, S. Campbell, H. Gamsu, T. Cohen-Overbeek, and J. M. Pearce, “Doppler studies in the growth retarded fetus and prediction of neonatal necrotising enterocolitis, haemorrhage, and neonatal morbidity,” British Medical Journal, vol. 294, no. 6563, pp. 13–16, 1987. View at Google Scholar · View at Scopus
  38. P. J. Beeby and H. Jeffery, “Risk factors for necrotising enterocolitis: the influence of gestational age,” Archives of Disease in Childhood, vol. 67, no. 4, pp. 432–435, 1992. View at Google Scholar · View at Scopus
  39. R. N. Goldberg, D. W. Thomas, and F. R. Sinatra, “Necrotizing enterocolitis in the asphyxiated full-term infant,” American Journal of Perinatology, vol. 1, no. 1, pp. 40–42, 1983. View at Google Scholar · View at Scopus
  40. A. Guven, G. Gundogdu, B. Uysal et al., “Hyperbaric oxygen therapy reduces the severity of necrotizing enterocolitis in a neonatal rat model,” Journal of Pediatric Surgery, vol. 44, no. 3, pp. 534–540, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Sullivan, R. J. Schanler, J. H. Kim et al., “An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products,” Journal of Pediatrics, vol. 156, no. 4, pp. 562.e1–567.e1, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Lucas and T. J. Cole, “Breast milk and neonatal necrotising enterocolitis,” The Lancet, vol. 336, no. 8730-8731, pp. 1519–1523, 1990. View at Google Scholar · View at Scopus
  43. W. McGuire and M. Y. Anthony, “Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 88, no. 1, pp. F11–F14, 2003. View at Google Scholar · View at Scopus
  44. R. J. Schanler, “Outcomes of human milk-fed premature infants,” Seminars in Perinatology, vol. 35, no. 1, pp. 29–33, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. R. J. McClure, “Trophic feeding of the preterm infant,” Acta Paediatrica. Supplement, vol. 90, no. 436, pp. 19–21, 2001. View at Google Scholar · View at Scopus
  46. R. J. McClure and S. J. Newell, “Randomised controlled study of clinical outcome following trophic feeding,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 82, no. 1, pp. F29–F33, 2000. View at Google Scholar · View at Scopus
  47. M. G. MacDonald, M. D. Kullet, and M. M. Seshia, Avery’s Neonatology. Pathophysiology and Management of the Newborn, Williams and Wilkins, Philadelphia, Pa, USA, 6th edition, 2005.
  48. C. L. Berseth, J. A. Bisquera, and V. U. Paje, “Prolonging small feeding volumes early in life decreases the incidence of necrotizing enterocolitis in very low birth weight infants,” Pediatrics, vol. 111, no. 3, pp. 529–534, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. G. Henderson, S. Craig, P. Brocklehurst, and W. McGuire, “Enteral feeding regimens and necrotising enterocolitis in preterm infants: a multicentre case-control study,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 94, no. 2, pp. F120–F123, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. I. Le Hurou-Luron, S. Blat, and G. Boudry, “Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects,” Nutrition Research Reviews, vol. 23, no. 1, pp. 23–36, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. S. J. Gross, R. J. David, L. Bauman, and R. M. Tomarelli, “Nutritional composition of milk produced by mothers delivering preterm,” Journal of Pediatrics, vol. 96, no. 4, pp. 641–644, 1980. View at Google Scholar · View at Scopus
  52. J. van Acker, F. de Smet, G. Muyldermans, A. Bougatef, A. Naessens, and S. Lauwers, “Outbreak of necrotizing enterocolitis associated with Enterobacter sakazakii in powdered milk formula,” Journal of Clinical Microbiology, vol. 39, no. 1, pp. 293–297, 2001. View at Publisher · View at Google Scholar · View at Scopus
  53. E. Weir, “Powdered infant formula and fatal infection with Enterobacter sakazakii,” Canadian Medical Association Journal, vol. 166, no. 12, p. 1570, 2002. View at Google Scholar · View at Scopus
  54. A. Fernández Polo, M. J. Cabañas Poy, S. Clemente Bautista, M. Oliveras Arenas, F. Castillo Salinas, and E. Hidalgo Albert, “Osmolality of oral liquid dosage forms to be administered to newborns in a hospital,” Farmacia Hospitalaria, vol. 31, no. 5, pp. 311–314, 2007. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Bruns, “Hyperosmolarity—a cause of necrotising enterocolitis? Osmolarity of therapeutic additives in premature infant feeding,” Krankenhauspharmazie, vol. 27, no. 2, pp. 63–69, 2006. View at Google Scholar · View at Scopus
  56. M. de Curtis, M. Candusso, C. Pieltain, and J. Rigo, “Effect of fortification on the osmolality of human milk,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 81, no. 2, pp. F141–F143, 1999. View at Google Scholar · View at Scopus
  57. L. Srinivasan, R. Bokiniec, C. King, G. Weaver, and A. D. Edwards, “Increased osmolality of breast milk with therapeutic additives,” Archives of Disease in Childhood: Fetal and Neonatal Edition, p. 89, 2004. View at Google Scholar
  58. J. Blau, J. M. Calo, D. Dozor, M. Sutton, G. Alpan, and E. F. La Gamma, “Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion,” Journal of Pediatrics, vol. 158, no. 3, pp. 403–409, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. C. D. Josephson, A. Wesolowski, G. Bao et al., “Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants?” Journal of Pediatrics, vol. 157, no. 6, pp. 972.e3–978.e3, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. R. D. Leake, B. Thanopoulos, and R. Nieberg, “Hyperviscosity syndrome associated with necrotizing enterocolitis,” American Journal of Diseases of Children, vol. 129, no. 10, pp. 1192–1194, 1975. View at Google Scholar · View at Scopus
  61. T. Gunn and E. Outerbridge, “Polycythemia as a cause of necrotizing enterocolitis,” Canadian Medical Association Journal, vol. 117, no. 5, p. 438, 1977. View at Google Scholar · View at Scopus
  62. Z. Ali, “A review of 36 babies with necrotizing enterocolitis,” Journal of Tropical Pediatrics, vol. 35, no. 6, pp. 274–276, 1989. View at Google Scholar · View at Scopus
  63. D. K. Lambert, R. D. Christensen, E. Henry et al., “Necrotizing enterocolitis in term neonates: data from a multihospital health-care system,” Journal of Perinatology, vol. 27, no. 7, pp. 437–443, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. N. A. Buch, S. M. Ahmad, S. W. Ali, and H. M. Hassan, “An epidemiological study of neonatal necrotizing enterocolitis,” Saudi Medical Journal, vol. 22, no. 3, pp. 231–237, 2001. View at Google Scholar · View at Scopus
  65. T. E. Wiswell, C. F. Robertson, T. A. Jones, and D. J. Tuttle, “Necrotizing enterocolitis in full-term infants. A case-control study,” American Journal of Diseases of Children, vol. 142, no. 5, pp. 532–535, 1988. View at Google Scholar · View at Scopus
  66. A. J. Clarke and J. R. Sibert, “Hypernatraemic dehydration and necrotizing enterocolitis,” Postgraduate Medical Journal, vol. 61, no. 711, pp. 65–66, 1985. View at Google Scholar · View at Scopus
  67. S. P. Dunn, K. R. Gross, L. R. Scherer, S. Moenning, A. Desanto, and J. L. Grosfeld, “The effect of polycythemia and hyperviscosity on bowel ischemia,” Journal of Pediatric Surgery, vol. 20, no. 4, pp. 324–327, 1985. View at Google Scholar · View at Scopus
  68. M. H. LeBlanc, C. D'Cruz, and K. Pate, “Necrotizing enterocolitis can be caused by polycythemic hyperviscosity in the newborn dog,” Journal of Pediatrics, vol. 105, no. 5, pp. 804–809, 1984. View at Google Scholar · View at Scopus
  69. WHO, “Polycythemia in the Newborn,” AIIMS- NICU protocols, 2007, http://www.newbornwhocc.org/.
  70. S. C. Springer, “Necrotizing Enterocolitis: Differential Diagnoses & Workup,” 2011, http://emedicine.medscape.com/article/977956-diagnosis.
  71. Y. Bayraktar and O. Harmanci, “Etiology and consequences of thrombosis in abdominal vessels,” World Journal of Gastroenterology, vol. 12, no. 8, pp. 1165–1174, 2006. View at Google Scholar · View at Scopus
  72. R. F. Burrows and J. G. Kelton, “Perinatal thrombocytopenia,” Clinics in Perinatology, vol. 22, no. 3, pp. 779–801, 1995. View at Google Scholar · View at Scopus
  73. A. B. Kenton, D. O'Donovan, D. L. Cass et al., “Severe thrombocytopenia predicts outcome in neonates with necrotizing enterocolitis,” Journal of Perinatology, vol. 25, no. 1, pp. 14–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  74. M. Ververidis, E. M. Kiely, L. Spitz, D. P. Drake, S. Eaton, and A. Pierro, “The clinical significance of thrombocytopenia in neonates with necrotizing enterocolitis,” Journal of Pediatric Surgery, vol. 36, no. 5, pp. 799–803, 2001. View at Publisher · View at Google Scholar · View at Scopus
  75. R. Saxena, M. Kannan, and V. P. Choudhry, “Neonatal thrombosis,” Indian Journal of Pediatrics, vol. 70, no. 11, pp. 903–907, 2003. View at Google Scholar · View at Scopus
  76. A. J. Clarke and J. R. Sibert, “Hypernatraemic dehydration and necrotizing enterocolitis,” Postgraduate Medical Journal, vol. 61, no. 711, pp. 65–66, 1985. View at Google Scholar · View at Scopus
  77. S. Oddie, S. Richmond, and M. Coulthard, “Hypernatraemic dehydration and breast feeding: a population study,” Archives of Disease in Childhood, vol. 85, no. 4, pp. 318–320, 2001. View at Publisher · View at Google Scholar · View at Scopus
  78. E. F. Bell and M. J. Acarregui, “Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD000503, 2008. View at Publisher · View at Google Scholar · View at Scopus
  79. D. Isaacs, J. North, D. Lindsell, and A. R. Wilkinson, “Serum acute phase reactants in necrotizing enterocolitis,” Acta Paediatrica Scandinavica, vol. 76, no. 6, pp. 923–927, 1987. View at Google Scholar · View at Scopus
  80. M. Hällström, A. M. Koivisto, M. Janas, and O. Tammela, “Laboratory parameters predictive of developing necrotizing enterocolitis in infants born before 33 weeks of gestation,” Journal of Pediatric Surgery, vol. 41, no. 4, pp. 792–798, 2006. View at Publisher · View at Google Scholar · View at Scopus
  81. N. Evennett, N. Alexander, M. Petrov, A. Pierro, and S. Eaton, “A systematic review of serologic tests in the diagnosis of necrotizing enterocolitis,” Journal of Pediatric Surgery, vol. 44, no. 11, pp. 2192–2201, 2009. View at Publisher · View at Google Scholar · View at Scopus
  82. P. H. Schober and J. Nassiri, “Risk factors and severity indices in necrotizing enterocolitis,” Acta Paediatrica. Supplement, vol. 83, no. 396, pp. 49–52, 1994. View at Google Scholar · View at Scopus
  83. R. Srinivasjois, E. Nathan, D. Doherty, and S. Patole, “Prediction of progression of definite necrotising enterocolitis to need for surgery or death in preterm neonates,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 23, no. 7, pp. 695–700, 2010. View at Publisher · View at Google Scholar · View at Scopus
  84. M. Pourcyrous, H. S. Bada, S. B. Korones, V. Baselski, and S. P. Wong, “Significance of serial C-reactive protein responses in neonatal infection and other disorders,” Pediatrics, vol. 92, no. 3, pp. 431–435, 1993. View at Google Scholar · View at Scopus
  85. M. Pourcyrous, H. S. Bada, S. B. Korones, F. F. Barrett, W. Jennings, and T. Lockey, “Acute phase reactants in neonatal bacterial infection,” Journal of Perinatology, vol. 11, no. 4, pp. 319–325, 1991. View at Google Scholar · View at Scopus
  86. M. Pourcyrous, S. B. Korones, W. Yang, T. F. Boulden, and H. S. Bada, “C-reactive protein in the diagnosis, management, and prognosis of neonatal necrotizing enterocolitis,” Pediatrics, vol. 116, no. 5, pp. 1064–1069, 2005. View at Publisher · View at Google Scholar · View at Scopus
  87. R. N. Goldberg, D. W. Thomas, and F. R. Sinatra, “Necrotizing enterocolitis in the asphyxiated full-term infant,” American Journal of Perinatology, vol. 1, no. 1, pp. 40–42, 1983. View at Google Scholar · View at Scopus
  88. B. Stoll, D. A. Horst, L. Cui et al., “Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs,” Journal of Nutrition, vol. 140, no. 12, pp. 2193–2200, 2010. View at Publisher · View at Google Scholar · View at Scopus
  89. P. J. Javid, S. Collier, D. Richardson et al., “The role of enteral nutrition in the reversal of parenteral nutrition-associated liver dysfunction in infants,” Journal of Pediatric Surgery, vol. 40, no. 6, pp. 1015–1018, 2005. View at Publisher · View at Google Scholar · View at Scopus
  90. P. J. Clarke, M. J. Ball, and M. G. W. Kettlewell, “Liver function tests in patients receiving parenteral nutrition,” Journal of Parenteral and Enteral Nutrition, vol. 15, no. 1, pp. 54–59, 1991. View at Google Scholar · View at Scopus
  91. D. A. K. Watters, S. Chamroonkul, and C. D. M. Griffith, “Changes in liver function tests associated with parenteral nutrition,” Journal of the Royal College of Surgeons of Edinburgh, vol. 29, no. 6, pp. 339–344, 1984. View at Google Scholar · View at Scopus
  92. G. Thuijls, J. P. M. Derikx, K. van Wijck et al., “Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis,” Annals of Surgery, vol. 251, no. 6, pp. 1174–1180, 2010. View at Publisher · View at Google Scholar · View at Scopus
  93. D. Carroll, A. Corfield, R. Spicer, and P. Cairns, “Faecal calprotectin concentrations and diagnosis of necrotising enterocolitis,” The Lancet, vol. 361, no. 9354, pp. 310–311, 2003. View at Publisher · View at Google Scholar · View at Scopus
  94. Q. Yang, P. B. Smith, R. N. Goldberg, and C. M. Cotten, “Dynamic change of fecal calprotectin in very low birth weight infants during the first month of life,” Neonatology, vol. 94, no. 4, pp. 267–271, 2008. View at Publisher · View at Google Scholar · View at Scopus
  95. T. Rand, M. Weninger, C. Kohlhauser et al., “Effects of umbilical arterial catheterization on mesenteric hemodynamics,” Pediatric Radiology, vol. 26, no. 7, pp. 435–438, 1996. View at Publisher · View at Google Scholar · View at Scopus
  96. A. Gentili, V. Landuzzi, L. Pasini, A. Pigna, A. Cacciari, and A. S. Corticelli, “Risk factors and protective factors in a population a risk for newborn necrotizing enterocolitis,” La Pediatria Medica e Chirurgica, vol. 18, no. 5, pp. 487–492, 1996. View at Google Scholar · View at Scopus
  97. S. O. Guthrie, P. V. Gordon, V. Thomas, J. A. Thorp, J. Peabody, and R. H. Clark, “Necrotizing enterocolitis among neonates in the United States,” Journal of Perinatology, vol. 23, no. 4, pp. 278–285, 2003. View at Publisher · View at Google Scholar · View at Scopus
  98. N. S. Kabra, M. Kumar, and S. S. Shah, “Multiple versus single lumen umbilical venous catheters for newborn infants,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD004498, 2005. View at Google Scholar · View at Scopus
  99. G. Parry, J. Tucker, and W. Tarnow-Mordi, “CRIB II: an update of the clinical risk index for babies score,” The Lancet, vol. 361, no. 9371, pp. 1789–1791, 2003. View at Publisher · View at Google Scholar · View at Scopus
  100. P. K. Rastogi, V. Sreenivas, and N. Kumar, “Validation of CRIB II for prediction of mortality in premature babies,” Indian Pediatrics, vol. 47, no. 2, pp. 145–147, 2010. View at Publisher · View at Google Scholar · View at Scopus
  101. J. Madan, J. Fiascone, V. Balasubramanian, J. Griffith, and J. I. Hagadorn, “Predictors of ductal closure and intestinal complications in very low birth weight infants treated with indomethacin,” Neonatology, vol. 94, no. 1, pp. 45–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  102. S. E. G. Hamrick and G. Hansmann, “Patent ductus arteriosus of the preterm infant,” Pediatrics, vol. 125, no. 5, pp. 1020–1030, 2010. View at Publisher · View at Google Scholar · View at Scopus
  103. R. L. Meyers, G. Alpan, E. Lin, and R. I. Clyman, “Patent ductus arteriosus, indomethacin, and intestinal distension: effects on intestinal blood flow and oxygen consumption,” Pediatric Research, vol. 29, no. 6, pp. 569–574, 1991. View at Google Scholar · View at Scopus
  104. D. O'Donovan, A. Baetiong, K. Adams et al., “Necrotizing enterocolitis and gastrointestinal complications after indomethacin therapy and surgical ligation in premature infants with patent ductus arteriosus,” Journal of Perinatology, vol. 23, no. 4, pp. 286–290, 2003. View at Publisher · View at Google Scholar · View at Scopus
  105. P. T. Nowicki, C. E. Miller, and R. C. Edwards, “Effects of hypoxia and ischemia on autoregulation in postnatal intestine,” American Journal of Physiology, vol. 261, no. 1, pp. G152–G157, 1991. View at Google Scholar · View at Scopus
  106. C. Michael Cotten, S. Taylor, B. Stoll et al., “Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants,” Pediatrics, vol. 123, no. 1, pp. 58–66, 2009. View at Publisher · View at Google Scholar · View at Scopus
  107. A. Tagare, S. Kadam, U. Vaidya, and A. Pandit, “Routine antibiotic use in preterm neonates: a randomised controlled trial,” The Journal of Hospital Infection, vol. 74, no. 4, pp. 332–336, 2010. View at Google Scholar · View at Scopus
  108. J. Madan, J. Fiascone, V. Balasubramanian, J. Griffith, and J. I. Hagadorn, “Predictors of ductal closure and intestinal complications in very low birth weight infants treated with indomethacin,” Neonatology, vol. 94, no. 1, pp. 45–51, 2008. View at Publisher · View at Google Scholar · View at Scopus
  109. G. A. Macones, S. J. Marder, B. Clothier, and D. M. Stamilio, “The controversy surrounding indomethacin for tocolysis,” American Journal of Obstetrics and Gynecology, vol. 184, no. 3, pp. 264–272, 2001. View at Publisher · View at Google Scholar · View at Scopus
  110. W. J. Morales and H. Madhav, “Efficacy and safety of indomethacin compared with magnesium sulfate in the management of preterm labor: a randomized study,” American Journal of Obstetrics and Gynecology, vol. 169, no. 1, pp. 97–102, 1993. View at Google Scholar · View at Scopus
  111. T. Kurki, M. Eronen, R. A. Lumme, and O. Ylikorkala, “A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor,” Obstetrics and Gynecology, vol. 78, no. 6, pp. 1093–1097, 1991. View at Google Scholar · View at Scopus
  112. S. Abbasi, J. S. Gerdes, H. M. Sehdev, S. S. Samimi, and J. Ludmir, “Neonatal outcome after exposure to indomethacin in utero: a retrospective case cohort study,” American Journal of Obstetrics and Gynecology, vol. 189, no. 3, pp. 782–785, 2003. View at Publisher · View at Google Scholar · View at Scopus
  113. S. B. Amin, R. A. Sinkin, and J. C. Glantz, “Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes,” American Journal of Obstetrics and Gynecology, vol. 197, no. 5, pp. 486.e1–486.e10, 2007. View at Publisher · View at Google Scholar · View at Scopus
  114. A. M. Fujii, E. Brown, M. Mirochnick, S. O'Brien, and G. Kaufman, “Neonatal necrotizing enterocolitis with intestinal perforation in extremely premature infants receiving early indomethacin treatment for patent ductus arteriosus,” Journal of Perinatology, vol. 22, no. 7, pp. 535–540, 2002. View at Publisher · View at Google Scholar · View at Scopus
  115. S. T. Vermillion and R. B. Newman, “Recent indomethacin tocolysis is not associated with neonatal complications in preterm infants,” American Journal of Obstetrics and Gynecology, vol. 181, no. 5, pp. 1083–1086, 1999. View at Publisher · View at Google Scholar · View at Scopus
  116. B. V. Parilla, W. A. Grobman W., R. B. Holtzman, H. A. Thomas, and S. L. Dooley, “Indomethacin tocolysis and risk of necrotizing enterocolitis,” Obstetrics and Gynecology, vol. 96, no. 1, pp. 120–123, 2000. View at Publisher · View at Google Scholar · View at Scopus
  117. N. A. Shorter, J. Y. Liu, D. P. Mooney, and B. J. Harmon, “Indomethacin-associated bowel perforations: a study of possible risk factors,” Journal of Pediatric Surgery, vol. 34, no. 3, pp. 442–444, 1999. View at Google Scholar · View at Scopus
  118. Y. Kawase, T. Ishii, H. Arai, and N. Uga, “Gastrointestinal perforation in very low-birthweight infants,” Pediatrics International, vol. 48, no. 6, pp. 599–603, 2006. View at Publisher · View at Google Scholar · View at Scopus
  119. J. L. Grosfeld, M. Chaet, F. Molinari et al., “Increased risk of necrotizing enterocolitis in premature infants with patent ductus arteriosus treated with indomethacin,” Annals of Surgery, vol. 224, no. 3, pp. 350–357, 1996. View at Publisher · View at Google Scholar · View at Scopus
  120. M. E. Norton, J. Merrill, B. A. B. Cooper, J. A. Kuller, and R. I. Clyman, “Neonatal complications after the administration of indomethacin for preterm labor,” New England Journal of Medicine, vol. 329, no. 22, pp. 1602–1607, 1993. View at Publisher · View at Google Scholar · View at Scopus
  121. R. Sharma, M. L. Hudak, J. J. Tepas 3rd et al., “Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis,” Journal of Perinatology, vol. 30, no. 12, pp. 786–793, 2010. View at Publisher · View at Google Scholar · View at Scopus
  122. P. C. Tsao, S. J. Chen, C. F. Yang et al., “Comparison of intravenous and enteral indomethacin administration for closure of patent ductus arteriosus in extremely-low-birth-weight infants,” Journal of the Chinese Medical Association, vol. 73, no. 1, pp. 15–20, 2010. View at Publisher · View at Google Scholar · View at Scopus
  123. H. L. Halliday, R. A. Ehrenkranz, and L. W. Doyle, “Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD001146, 2009. View at Publisher · View at Google Scholar · View at Scopus
  124. D. E. da Costa, P. A. K. Nair, and S. M. Al Khusaiby, “Effects of antenatal steroids on the complications of prematurity in an era of surfactant replacement therapy in Oman,” Journal of Tropical Pediatrics, vol. 46, no. 6, pp. 375–377, 2000. View at Publisher · View at Google Scholar · View at Scopus
  125. R. C. Pattinson, J. D. Makin, M. Funk et al., “The use of dexamethasone in women with preterm premature rupture of membranes—a multicentre, double-blind, placebo-controlled, randomised trial,” South African Medical Journal, vol. 89, no. 8, pp. 865–870, 1999. View at Google Scholar · View at Scopus
  126. D. Roberts and S. Dalziel, “Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth,” Cochrane Database of Systematic Reviews, vol. 3, Article ID CD004454, 2006. View at Google Scholar · View at Scopus
  127. H. L. Halliday, R. A. Ehrenkranz, and L. W. Doyle, “Late (>7 days) postnatal corticosteroids for chronic lung disease in preterm infants,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD001145, 2009. View at Google Scholar · View at Scopus
  128. G. Deshpande, S. Rao, and S. Patole, “Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials,” The Lancet, vol. 369, no. 9573, pp. 1614–1620, 2007. View at Publisher · View at Google Scholar · View at Scopus
  129. C. Czyrko, C. A. Del Pin, J. A. O'Neill Jr., G. J. Peckham, and A. J. Ross 3rd, “Maternal cocaine abuse and necrotizing enterocolitis: outcome and survival,” Journal of Pediatric Surgery, vol. 26, no. 4, pp. 414–421, 1991. View at Publisher · View at Google Scholar · View at Scopus