Table 2: Stability of conventional and PEGylated vancomycin liposomes at the end of 1, 2 and 3 months.

FormulationTest conditionTemp% EEParticle size (nm)Physical appearance

Conventional liposomes0 Mon12.40 2 3 4 ± 9 2 Milky suspension
1 Mon4°C11.71 2 5 8 ± 1 1 1 Milky suspension
24°C8.68 2 4 2 ± 9 7 Milky suspension; slight coagulation
37°C4.28 6 0 5 ± 8 0 0 Slightly dark color and thicker suspension, with growth of fungus on top, dispersed upon shaking.
2 Mon4°C8.47 2 6 0 ± 8 5 Milky suspension
24°C5.01 3 0 5 ± 1 1 2 Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking.
3 Mon4°C 8.23 2 5 0 ± 9 7 Milky suspension
24°C 3.67 3 5 6 ± 4 3 Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking

PEGylated liposomes0 Mon12.78 1 8 1 ± 8 2 Milky suspension
1 Mon4°C11.17 2 0 2 ± 1 0 7 Milky suspension
24°C9.40 2 0 0 ± 1 0 6 Milky suspension; slight coagulation
37°C6.90 2 0 8 ± 1 0 9 Slightly dark color and thicker suspension, with growth of fungus on top, dispersed upon shaking.
2 Mon4°C10.33 2 0 5 ± 9 3 Milky suspension
24°C5.29 3 5 5 ± 1 5 4 Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking.
3 Mon4°C9.89 2 1 0 ± 8 8 Milky suspension
24°C4.98 2 9 0 ± 1 2 0 Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking