Table of Contents
ISRN Oncology
Volume 2012, Article ID 638352, 6 pages
Clinical Study

Time-Dependent Changes of Plasma Concentrations of Angiopoietins, Vascular Endothelial Growth Factor, and Soluble Forms of Their Receptors in Nonsmall Cell Lung Cancer Patients Following Surgical Resection

1Department of Pathobiochemistry and Clinical Chemistry, College of Medicine, Nicolaus Copernicus University, M. Skłodowska-Curie 9 Street, 85-094 Bydgoszcz, Poland
2Department of Thoracic Surgery and Tumors, Oncology Centre, dr I. Romanowska 2 Street, 85-796 Bydgoszcz, Poland
3Department of Oncology and Brachytherapy, College of Medicine, Nicolaus Copernicus University and Oncology Centre, dr I. Romanowska 2 Street, 85-796 Bydgoszcz, Poland
4Department of Laboratory Diagnostics, Oncology Centre in Bydgoszcz, dr I. Romanowska 2 Street, 85-796 Bydgoszcz, Poland

Received 2 January 2012; Accepted 22 January 2012

Academic Editors: J. Klijanienko and S. Ran

Copyright © 2012 Ewa Kopczyńska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Even when patients with nonsmall cell lung cancer undergo surgical resection at an early stage, recurrent disease often impairs the clinical outcome. There are numerous causes potentially responsible for a relapse of the disease, one of them being extensive angiogenesis. The balance of at least two systems, VEGF VEGFR and Ang Tie, regulates vessel formation. The aim of this study was to determine the impact of surgery on the plasma levels of the main angiogenic factors during the first month after surgery in nonsmall cell lung cancer patients. The study group consisted of 37 patients with stage I nonsmall cell lung cancer. Plasma concentrations of Ang1, Ang2, sTie2, VEGF, and sVEGF R1 were evaluated by ELISA three times: before surgical resection and on postoperative days 7 and 30. The median of Ang2 and VEGF concentrations increased on postoperative day 7 and decreased on day 30. On the other hand, the concentration of sTie2 decreased on the 7th day after resection and did not change statistically later on. The concentrations of Ang1 and sVEGF R1 did not change after the surgery. Lung cancer resection results in proangiogenic plasma protein changes that may stimulate tumor recurrences and metastases after early resection.