Table of Contents
ISRN Oncology
Volume 2012, Article ID 642106, 10 pages
http://dx.doi.org/10.5402/2012/642106
Review Article

Trends in Kaposi’s Sarcoma in Miami Beach from 1987 to 2007

1Department of Internal Medicine, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA
2Department of Hematology and Oncology, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
3Department of Public Health and Biostatistics, College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale-Davie, FL 33314, USA
4Department of Clinical Psychology, Nova Southeastern University, Fort Lauderdale-Davie, FL 33314, USA

Received 15 November 2012; Accepted 9 December 2012

Academic Editors: A. Berner and L. Hunakova

Copyright © 2012 Simon B. Zeichner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Kaposi’s sarcoma (KS) is a rare low-grade vascular tumor associated with the human herpes virus 8. By analyzing the epidemiology, staging, and treatment of KS, we hoped to improve the quality of care at our institution. Methods. Review of the Mount Sinai Medical Center tumor registry database in Miami Beach, FL, USA, identified 143 cases of KS between January 1, 1987 and December 31, 2007. Results. The majority of patients were non-Hispanic whites, non smoking males diagnosed between 1987 and 1996. Most of the patients were HIV positive, with an equal percentage diagnosed with local or distant disease. Most patients received no chemotherapy or radiation. There were no significant differences in patient survival based on sex, HIV status, or radiation received. There was a trend toward improved survival among older patients who smoked, received no chemotherapy, and had localized stage at diagnosis. Multivariate analysis revealed that non-Hispanic whites had a significant worse survival than Hispanic whites (HR = 0.55, 95% CI (0.33, 0.90), ). Patients diagnosed between 1987 and 1996 had a worse survival than those between 1997 and 2007 (HR = 0.33 (95% CI 0.19, 0.55), ). Conclusion. This large retrospective study provides further insight into KS. Ethnicity and date of diagnosis are important predictors of long-term survival.