Table of Contents
ISRN Psychiatry
Volume 2012, Article ID 651613, 6 pages
Clinical Study

Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599

1Department of Pharmaceutical Technology, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece
2Department 10th of Dafni-Attica’s Psychiatric Hospital, Athinon Avenue 374, Haidari, 12462 Athens, Greece
3Departments of Biochemistry and Molecular Biology, School of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece
4Research Diagnostics, Spin-off Company of the University of Athens, Panepistimiopolis, 15771 Athens, Greece

Received 5 September 2012; Accepted 26 September 2012

Academic Editors: B. J. Mitterauer and T. van Erp

Copyright © 2012 Kotrotsou Maria et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Schizophrenia, a severe psychiatric condition, is characterized by disturbances of cognition, emotion, and social functioning. The disease affects almost 1% of world population. Recent studies evaluating the role of catechol-O-methyltransferase enzyme (COMT) polymorphisms in the pathogenesis of schizophrenia have resulted in ambiguous findings. The current study examined the association of schizophrenia with three COMT polymorphisms, namely, rs737865, rs4680, and rs165599 in a Greek population. There was no significant association between schizophrenia and any of the three SNPs examined. However, haplotype analysis showed that cases have higher frequency of the T-A-A haplotype, and participants with that haplotype were at increased risk for developing schizophrenia (OR = 1.52; CL : 1.12–2.08; ). Furthermore, patients with schizophrenia displayed an excess of TC/AA/AA and the TT/AA/GA genotypes. Similarly a protective effect of TT/GG/GG and TT/GA/GG was suggested by our results.