Table of Contents
ISRN Psychiatry
Volume 2012, Article ID 651613, 6 pages
http://dx.doi.org/10.5402/2012/651613
Clinical Study

Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599

1Department of Pharmaceutical Technology, School of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 15771 Athens, Greece
2Department 10th of Dafni-Attica’s Psychiatric Hospital, Athinon Avenue 374, Haidari, 12462 Athens, Greece
3Departments of Biochemistry and Molecular Biology, School of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, 15701 Athens, Greece
4Research Diagnostics, Spin-off Company of the University of Athens, Panepistimiopolis, 15771 Athens, Greece

Received 5 September 2012; Accepted 26 September 2012

Academic Editors: B. J. Mitterauer and T. van Erp

Copyright © 2012 Kotrotsou Maria et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. J. Bray and M. J. Owen, “Searching for schizophrenia genes,” Trends in Molecular Medicine, vol. 7, no. 4, pp. 169–174, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. M. C. O'Donovan, N. M. Williams, and M. J. Owen, “Recent advances in the genetics of schizophrenia,” Human Molecular Genetics, vol. 12, no. 2, pp. R125–R133, 2003. View at Google Scholar · View at Scopus
  3. P. T. Männistö and S. Kaakkola, “Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors,” Pharmacological Reviews, vol. 51, no. 4, pp. 593–628, 1999. View at Google Scholar · View at Scopus
  4. M. J. Owen, M. C. O'Donovan, and P. J. Harrison, “Schizophrenia: a genetic disorder of the synapse?” British Medical Journal, vol. 330, no. 7484, pp. 158–159, 2005. View at Google Scholar · View at Scopus
  5. K. L. Davis, R. S. Kahn, G. Ko, and M. Davidson, “Dopamine in schizophrenia: a review and reconceptualization,” American Journal of Psychiatry, vol. 148, no. 11, pp. 1474–1486, 1991. View at Google Scholar · View at Scopus
  6. A. Meyer-Lindenberg, T. Nichols, J. H. Callicott et al., “Impact of complex genetic variation in COMT on human brain function,” Molecular Psychiatry, vol. 11, no. 9, pp. 867–877, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. T. M. Maynard, G. T. Haskell, J. A. Lieberman, and A. S. LaMantia, “22q11 DS: genomic mechanisms and gene function in DiGeorge/velocardiofacial syndrome,” International Journal of Developmental Neuroscience, vol. 20, no. 3–5, pp. 407–419, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. K. C. Murphy, “Schizophrenia and velo-cardio-facial syndrome,” Lancet, vol. 359, no. 9304, pp. 426–430, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. H. M. Lachman, D. F. Papolos, T. Saito, Y. M. Yu, C. L. Szumlanski, and R. M. Weinshilboum, “Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders,” Pharmacogenetics, vol. 6, no. 3, pp. 243–250, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Lotta, J. Vidgren, C. Tilgmann et al., “Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme,” Biochemistry, vol. 34, no. 13, pp. 4202–4210, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. M. F. Egan, T. E. Goldberg, B. S. Kolachana et al., “Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 12, pp. 6917–6922, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. T. E. Goldberg, M. F. Egan, T. Gscheidle et al., “Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia,” Archives of General Psychiatry, vol. 60, no. 9, pp. 889–896, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Li, P. C. Sham, H. Vallada et al., “Preferential transmission of the high activity allele of COMT in schizophrenia,” Psychiatric Genetics, vol. 6, no. 3, pp. 131–133, 1996. View at Google Scholar · View at Scopus
  14. S. J. Glatt, S. V. Faraone, and M. T. Tsuang, “Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies,” American Journal of Psychiatry, vol. 160, no. 3, pp. 469–476, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. M. R. Munafò, L. Bowes, T. G. Clark, and J. Flint, “Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies,” Molecular Psychiatry, vol. 10, no. 8, pp. 765–770, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. F. Egan, T. E. Goldberg, B. S. Kolachana et al., “Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 12, pp. 6917–6922, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Shifman, M. Bronstein, M. Sternfeld et al., “A highly significant association between a COMT haplotype and schizophrenia,” American Journal of Human Genetics, vol. 71, no. 6, pp. 1296–1302, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Chen, X. Wang, A. F. O'Neill, D. Walsh, and K. S. Kendler, “Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families,” Molecular Psychiatry, vol. 9, no. 10, pp. 962–967, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Y. Handoko, D. R. Nyholt, N. K. Hayward et al., “Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia,” Molecular Psychiatry, vol. 10, no. 6, pp. 589–597, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. Palmatier, A. M. Kang, and K. K. Kidd, “Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles,” Biological Psychiatry, vol. 46, no. 4, pp. 557–567, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Funke, A. K. Malhotra, C. T. Finn et al., “COMT genetic variation confers risk for psychotic and affective disorders: a case control study,” Behavioral and Brain Functions, vol. 1, article no. 19, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. B. A. Salisbury, M. Pungliya, J. Y. Choi, R. Jiang, X. J. Sun, and J. C. Stephens, “SNP and haplotype variation in the human genome,” Mutation Research—Fundamental and Molecular Mechanisms of Mutagenesis, vol. 526, no. 1-2, pp. 53–61, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. S. E. Hyman and W. S. Fenton, “Medicine: what are the right targets for psychopharmacology?” Science, vol. 299, no. 5605, pp. 350–351, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. N. J. Bray, P. R. Buckland, N. M. Williams et al., “A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain,” American Journal of Human Genetics, vol. 73, no. 1, pp. 152–161, 2003. View at Publisher · View at Google Scholar · View at Scopus