Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599

Table 3

Single SNP Analysis: logistic regression-derived, crude odds ratios (OR), 95% confidence intervals (95% CI), and 𝑃 values for the risk of schizophrenia in each SNP (rs737865, rs4680, and rs165599) according to the recessive, dominant, additive genetic models, and analysis per allele in the total of 205 participants.

Polymorphisms	Crude odds ratio analysis
	OR	95% CI	𝑃 value
rs737865
Recessive model
CC versus TT + TC	0.68	0.24–1.90	0.459*
Dominant model
CC + TC versus TT	0.90	0.51–1.57	0.705*
Additive model
C allele versus TT	0.87	0.55–1.36	0.528**
Analysis per allele
C allele versus T allele	0.89	0.59–1.34	0.565*
rs4680
Recessive model
AA versus GG + GA	1.56	0.77–3.19	0.221*
Dominant model
AA + GA versus GG	1.10	0.59–2.05	0.758*
Additive model
A allele versus GG	1.21	0.81–1.83	0.358**
Analysis per allele
A allele versus G allele	1.19	0.81–1.76	0.380*
rs165599
Recessive model
AA versus GG + GA	1.40	0.76–2.58	0.286*
Dominant model
AA + GA versus GG	1.23	0.55–2.77	0.612*
Additive model
A allele versus GG	1.26	0.81–1.96	0.298**
Analysis per allele
A allele versus G allele	1.21	0.81–1.79	0.350*

∗P values derived from Wald test.
∗∗P values derived from Armitage test for trend.