Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599

Table 4

Haplotype analysis: frequencies and logistic regression-derived odds ratios (OR) for the risk of schizophrenia in the study participants.

Haplotypes; rs737865/4680/165599	Patients 𝑁 (%)	Controls 𝑁 (%)	OR	95% CI	P value^†
T/G/G	133 (15.5)	144 (18.6)	Baseline	—	—
T/A/A	225 (26.0)	160 (20.6)	1.52	1.12–2.08	0.008
T/G/A	139 (16.1)	118 (15.2)	1.28	0.91–1.79	0.161
C/G/G	103 (11.9)	90 (11.6)	1.24	0.86–1.79	0.254
C/G/A	77 (8.9)	84 (10.8)	0.99	0.67–1.46	0.970
T/A/G	83 (9.6)	78 (10.1)	1.15	0.78–1.70	0.475
C/A/A	71 (8.2)	66 (8.5)	1.17	0.77–1.76	0.466
C/A/G	33 (3.8)	36 (4.6)	0.99	0.59–1.68	0.978

†P values derived from Wald test.