Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599

Table 5

Frequencies of all possible combinations of genotypes from which arises the T/A/A haplotype and logistic regression-derived odds ratios (OR) for the risk of schizophrenia.

rs737865	rs4680	rs165599	Patients 𝑁(%)	Controls 𝑁(%)	Total 𝑁 (%)	OR	95% CI	P value^†
T/T	A/A	A/A	80 (35.6)	64 (40.0)	144 (37.4)	Baseline	—	—
T/T	G/A	G/A	32 (14.2)	26 (16.2)	58 (15.1)	0.99	0.53–11.82	0.961
T/C	G/A	G/A	21 (9.4)	24 (15.0)	45 (11.7)	0.70	0.36–1.37	0.298
T/T	G/A	A/A	32 (14.2)	16 (10.0)	48 (12.5)	1.60	0.81–3.17	0.178
T/C	A/A	A/A	32 (14.2)	12 (7.5)	44 (11.4)	2.13	1.02–4.47	0.045
T/C	G/A	A/A	10 (4.4)	12 (7.5)	22 (5.7)	0.67	0.27–1.64	0.378
T/T	A/A	G/A	16 (7.1)	4 (2.5)	20 (5.2)	3.20	1.02–10.05	0.046
T/C	A/A	G/A	2 (0.9)	2 (1.3)	4 (1.0)	0.80	0.11–5.84	0.826

^†P values derived from Wald test.