Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls: A Study of SNPs rs737865, rs4680, and rs165599

Table 6

Frequencies of all possible combinations of T/G/G and logistic regression-derived odds ratios (OR) for the risk of schizophrenia.

rs737865	rs4680	rs165599	Patients 𝑁 (%)	Controls 𝑁 (%)	Total 𝑁 (%)	OR	95% CI	𝑃 value^†
T/T	G/A	G/A	40 (30.1)	26 (18.0)	66 (23.7)	Baseline	—	—
T/C	G/G	G/G	28 (21.1)	16 (11.1)	44 (15.9)	1.14	0.52–2.50	0.749
T/C	G/A	G/A	21 (15.7)	24 (16.7)	45 (16.3)	0.57	0.26–1.22	0.149
T/C	G/G	G/A	24 (18.1)	20 (13.9)	44 (15.9)	0.78	0.36–1.69	0.528
T/T	G/G	G/G	8  (6.0)	24  (16.7)	32  (11.6)	0.22	0.09–0.56	0.001
T/T	G/A	G/G	8  (6.0)	16  (11.1)	24  (8.7)	0.33	0.12–0.87	0.025
T/T	G/G	G/A	4 (3.0)	16 (11.1)	20 (7.2)	n/a	n/a	n/a
T/C	G/A	G/G	0 (0.0)	2 (1.4)	2 (0.7)	n/a	n/a	n/a

†P values derived from Wald test.
Due to small frequencies, the combinations T/T-G/G-G/A and T/C-G/A-G/G were not included in the model.