Table of Contents
ISRN Oncology
Volume 2012, Article ID 652682, 7 pages
http://dx.doi.org/10.5402/2012/652682
Research Article

Prognostic Biomarkers and EBV Infection Research in Diffuse Large B-Cell Lymphoma of the Palatine Tonsils

1Serviço de Hematologia, Núcleo de Oncologia da Bahia, Avenida Adhemar de Barros 123, Ondina, 40170-110 Salvador, BA, Brazil
2Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Rua Augusto Viana s/n, 40110-060 Salvador, BA, Brazil
3Institute of Pathology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
4Serviço de Hematologia, Hospital Aristides Maltez, Avenida D. João VI 332, Brotas, 40285-001 Salvador, BA, Brazil

Received 8 October 2011; Accepted 13 November 2011

Academic Editors: M. Emoto and N. A. Franken

Copyright © 2012 Marinho Marques et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diffuse large B-cell lymphoma represents approximately 30%–40% of all diagnoses of non-Hodgkin’s Lymphoma and may represent up to 80% of all lymphomas that arise in the palatine tonsils. Several studies have attempted to correlate clinical, laboratorial, and tissue factors with the prognosis of the lymphomas, such as the International Prognostic Index, the tissue expression of some proteins, and the lymphocyte count at the time of diagnosis, as well as to correlate Epstein-Barr virus (EBV) infection with worse prognoses. Patients with palatine tonsil DLBCL, from Salvador, Bahia, Brazil, were studied in order to identify prognostic factors. Twenty-four patients with DLBCL were studied. The factors that negatively influenced the patients’ survival rates were the lymphocyte count at the time of diagnosis <1.000/mm3 and the Bcl-2 protein expression. There was no CD5 expression in these lymphomas, and neither was there an association with EBV infection.