Emotion Processing in Women with Schizophrenia Is Menstrual Cycle Phase and Affective Valence Dependent: An fMRI Study

Table 5

Cerebral activations during processing of negative emotions in control and schizophrenia women during the luteal phase.

Anatomical area	L/R	Control women						Schizophrenia women
		BA	MNI coordinates			Z-score	Voxels	BA	MNI coordinates			Z-score	Voxels
			x	y	z				x	y	z
Fusiform	R	19	32	−77	−18	6.78	7436	19	38	−70	−18	5.05	4678
	L	37	−38	−46	−24	6.12	*	19	−38	−74	−18	5.62	*
Calcarine	L	17	−7	−98	0	6.28	*	17	−4	−91	−4	5.68	*
Cuneus	R	19	10	−98	21	6.33	*
Middle occipital	R	19	32	−91	14	7.40	*
	L	19	−28	−84	21	5.85	*	19	−28	−94	14	6.19	*
Inferior occipital	R							18	42	−84	−7	5.71	*
Inferior temporal	R	19	49	−74	−7	7.43	*	22	42	−60	14	3.54	*
Thalamus	L	—	−21	−24	0	5.85	*
	R	—	24	−28	7	5.69	*	—	21	−28	4	3.47	7
Amygdala	R	—	28	0	−14	4.32	14
Insula	L	13	−32	24	0	4.46	36
Anterior temporal pole	R							38	42	24	−28	3.61	7
Cerebellum	L	–	−38	−74	−21	5.65	7436	—	−21	−32	−46	3.47	6
	R	–	10	−70	−42	5.21	*	—	24	−32	−46	3.41	9
Supramarginal	R	40	46	−32	42	4.74	182
Inferior parietal	R	7	28	−52	49	4.50	*
	L							7	−32	−52	52	4.1	119
Postcentral	L							40	−49	−32	49	3.57	*
Superior parietal	L							7	−28	−60	52	3.93	*
Precentral	L	9	−56	10	32	4.67	193
	R							6	42	−7	49	3.32	6
Inferior frontal	R	9	52	14	24	5.63	222	9	46	10	24	3.63	52
	L	46	−46	28	21	5.08	193
Middle frontal	L							6	−28	−7	49	3.87	51
Superior medial frontal	L	32	−4	18	42	3.89	70
Superior frontal	R	6	35	−4	66	4.75	29
Inferior OFC	R	11	42	35	−14	4.63	40
	L	47	−46	35	−14	3.91	6	47	−32	28	−21	4.08	18
SMA	R	8	4	14	56	4.23	70
		Controls greater than patients						Patients greater than controls
Fusiform	L	20	−38	−14	−24	3.00	1376
Calcarine	L	18	−4	−102	0	3.34	25
Cuneus	R	7	14	−77	32	2.99	14
Heschl	L	13	−32	−32	10	4.00	1376
Superior temporal	R	22	66	−10	7	3.35	15
Inferior temporal	R	20	60	−18	−24	3.09	9
Thalamus	L	—	−24	−24	7	3.60	1376
	R	—	10	−10	7	3.22	*
Hippocampus	R	—	14	−38	7	3.80	*
Insula	L	—	−35	0	10	3.19	*
Inferior parietal	L	7	−24	−52	52	4.05	90
	R							40	56	−60	38	3.02	7
Superior parietal	R	7	21	−56	56	3.20	38
Inferior frontal	L	46	−42	32	24	3.67	117
	R	45	52	35	7	3.01	6
Middle OFC	R	11	38	52	−14	3.09	10

L: left; R: right; BA: Brodmann area; SMA: supplementary motor area; OFC: orbitofrontal cortex; P uncorrected ≤0.001.