Clinical Study

Emotion Processing in Women with Schizophrenia Is Menstrual Cycle Phase and Affective Valence Dependent: An fMRI Study

Table 8

Correlations between hormone levels and cerebral activations during processing of emotion (negative and positive) in control and schizophrenia women.

CorrelationGroupAnatomical areaL/RBAMNI coordinatesZ-scoreVoxels
xyz

Estrogen

Negative emotion
+CWCerebellumR24−60−423.1413
Superior frontalL6−2121603.1831
+SZWParahippocampalL28−21−21−213.6821

Positive emotion
CWInferior parietalL40−38−32383.2320
AmygdalaL−24−4−143.1424
Inferior frontalR133810243.109
Posterior cingulateL29−4−42103.0146
+SZWInferior parietalR4035−42523.0917
CerebellumR18−32−212.9829

Progesterone

Positive emotion
HWAnterior temporal poleL38−5614−183.3613
Superior medial frontalR101060143.0318

L: left; R: right; BA: Brodmann area; (−): negative correlation; (+): positive correlation; CW: control women; SZW: schizophrenia women; P uncorrected ≤0.001.