Clinical Study
Emotion Processing in Women with Schizophrenia Is Menstrual Cycle Phase and Affective Valence Dependent: An fMRI Study
Table 8
Correlations between hormone levels and cerebral activations during processing of emotion (negative and positive) in control and schizophrenia women.
| Correlation | Group | Anatomical area | L/R | BA | MNI coordinates | Z-score | Voxels | x | y | z |
| Estrogen | |
| Negative emotion | + | CW | Cerebellum | R | — | 24 | −60 | −42 | 3.14 | 13 | − | | Superior frontal | L | 6 | −21 | 21 | 60 | 3.18 | 31 | + | SZW | Parahippocampal | L | 28 | −21 | −21 | −21 | 3.68 | 21 |
| Positive emotion | − | CW | Inferior parietal | L | 40 | −38 | −32 | 38 | 3.23 | 20 | | | Amygdala | L | — | −24 | −4 | −14 | 3.14 | 24 | | | Inferior frontal | R | 13 | 38 | 10 | 24 | 3.10 | 9 | | | Posterior cingulate | L | 29 | −4 | −42 | 10 | 3.01 | 46 | + | SZW | Inferior parietal | R | 40 | 35 | −42 | 52 | 3.09 | 17 | | | Cerebellum | R | — | 18 | −32 | −21 | 2.98 | 29 |
| Progesterone | |
| Positive emotion | − | HW | Anterior temporal pole | L | 38 | −56 | 14 | −18 | 3.36 | 13 | | | Superior medial frontal | R | 10 | 10 | 60 | 14 | 3.03 | 18 |
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L: left; R: right; BA: Brodmann area; (−): negative correlation; (+): positive correlation; CW: control women; SZW: schizophrenia women; P uncorrected ≤0.001.
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