Analgesic and Toxicity Studies of Aminoacetylenic Isoindoline-1,3-dione Derivatives

Figure 2

Reduction of acetic acid-induced writhing response in mice following treatment with aspirin, ZM4, and ZM5. Values are expressed as mean ± S.E.M. (𝑛=9). Symbols represent statistical significance against 0 mg/kg dose as ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.