(a) Mixed modeling comparing mean OTM per week from baseline to week 8 for weekly aligner versus biweekly control groups
Group
Mean/Wk ± SD
P value
Weekly aligner Biweekly control
0.812
(b) Mixed modeling comparing the mean magnitude of OTM per week expressed during each two-week prescription cycle
Group
Interval
Mean/Wk ± SD
P value
Weekly aligner
Week 1-2
0.176
Week 3-4
Week 5-6
Week 7-8
Biweekly control
Week 1-2
0.297
Week 3-4
Week 5-6
Week 7-8
(c) Mixed modeling comparing OTM during the first week versus second week for the weekly aligner and biweekly control groups, both separately and combined