Organ-Tissue Level Model of Resting Energy Expenditure Across Mammals: New Insights into Kleiber's Law

Table 2

The organ-tissue level body composition, specific metabolic rates, and resting energy expenditure in 111 mammalian species.

Species	𝑀	𝐾𝐿	𝐾𝐵	𝐾𝐻	𝐾𝐾	𝐾𝑅	𝑇𝐿	𝑇𝐵	𝑇𝐻	𝑇𝐾	𝑇𝑅	REE𝑝	REE𝑘	(REE/𝑀)𝑝	(REE/𝑀)𝑘
Sorex araneus	0.0075	2533	896	1586	1037	67.7	0.00038	0.00015	0.00011	0.00011	0.0068	1.8	1.8	245	238
Crocidura russula	0.010	2376	866	1542	1016	65.1	0.00055	0.00017	0.00008	0.00013	0.0086	2.3	2.1	237	224
Lasiurus borealis	0.014	2165	824	1480	987	61.4	0.00035	0.00017	0.00014	0.00011	0.013	2.0	2.8	148	205
Lasionycteris noctivagans	0.015	2115	814	1465	980	60.5	0.00033	0.00016	0.00016	0.00013	0.014	2.0	3.0	138	201
Mus musculus	0.015	2108	812	1463	979	60.4	0.00068	0.00036	0.00007	0.00028	0.014	2.9	3.0	196	200
Myodes glareolus	0.015	2087	808	1456	976	60.0	0.00067	0.00035	0.00010	0.00024	0.014	2.9	3.1	188	198
Microtus agrestis	0.015	2087	808	1456	976	60.0	0.00063	0.00039	0.00012	0.00017	0.014	2.8	3.1	183	198
Neomys fodiens	0.016	2080	807	1454	975	59.9	0.00055	0.00025	0.00014	0.00022	0.015	2.6	3.1	168	198
Blarina brevicauda	0.018	2011	792	1433	965	58.6	0.00093	0.00032	0.00018	0.00021	0.016	3.5	3.4	199	192
Apodemus sylvaticus	0.018	1997	789	1428	963	58.4	0.0011	0.00057	0.00014	0.00026	0.016	4.0	3.5	221	190
Microtus pinetorum	0.021	1925	774	1405	952	57.1	0.0011	0.00058	0.00015	0.00036	0.019	4.3	3.9	204	184
Peromyscus leucopus	0.022	1897	768	1396	947	56.6	0.0012	0.00074	0.00015	0.00030	0.020	4.5	4.0	204	182
Apodemus flavicollis	0.025	1835	755	1376	938	55.4	0.0010	0.00061	0.00018	0.00034	0.023	4.1	4.4	164	176
Nyctalus noctula	0.026	1824	752	1372	936	55.2	0.0005	0.00032	0.00037	0.00013	0.024	3.0	4.5	119	175
Microtus arvalis	0.027	1799	747	1364	932	54.7	0.0019	0.00039	0.00019	0.00055	0.024	5.7	4.7	213	173
Mouse	0.028	1781	743	1358	929	54.4	0.0018	0.00050	0.00016	0.00051	0.025	5.6	4.8	199	171
Gerbillus perpallidus	0.030	1748	735	1347	924	53.7	0.0010	0.00058	0.00013	0.00027	0.028	4.0	5.1	135	168
Mustela nivalis	0.032	1714	728	1335	918	53.1	0.0016	0.0018	0.00036	0.00043	0.028	6.3	5.3	196	165
Acomys minous	0.042	1593	700	1293	897	50.7	0.0009	0.0009	0.00018	0.00032	0.040	4.7	6.5	110	254
Jaculus jaculus	0.048	1543	688	1275	888	49.7	0.0011	0.0012	0.00045	0.00029	0.045	5.6	7.2	117	150
Rhabdomys pumilio	0.050	1523	683	1267	885	49.3	0.0018	0.0006	0.00021	0.00041	0.047	6.2	7.4	123	148
Talpa europaea	0.051	1514	681	1264	883	49.2	0.0015	0.0010	0.00031	0.00036	0.048	6.1	7.6	118	147
Glaucomys volans	0.055	1486	675	1254	878	48.6	0.0029	0.0019	0.00056	0.00059	0.049	9.2	8.0	167	144
Arvicola terrestris	0.062	1441	664	1237	870	47.7	0.0026	0.0011	0.00028	0.00070	0.057	8.1	8.7	131	140
Glis glis	0.083	1330	636	1194	848	45.3	0.0032	0.0015	0.00048	0.00068	0.078	9.9	10.9	118	130
Tamias striatus	0.104	1254	616	1163	833	43.7	0.0029	0.0024	0.00066	0.00081	0.097	10.8	12.8	104	123
Octodon degus	0.129	1182	597	1134	818	42.1	0.0048	0.0019	0.00041	0.0011	0.121	13.3	15.1	103	117
Tupaia glis	0.141	1156	590	1122	812	41.5	0.0034	0.0034	0.00117	0.0011	0.132	13.6	16.1	96.9	114
Rat	0.150	1137	585	1114	808	41.1	0.0092	0.0023	0.00070	0.0014	0.136	19.3	16.9	129	112
Cebuella pygmaea	0.163	1112	578	1103	802	40.5	0.0135	0.0044	0.00086	0.0019	0.142	25.8	18.0	158	110
Rattus norvegicus	0.210	1039	558	1071	786	38.9	0.0092	0.0023	0.00087	0.0015	0.196	20.6	21.7	98.0	103
Cheirogaleus medius	0.231	1012	550	1059	779	38.3	0.0063	0.0028	0.00093	0.0010	0.220	18.1	23.3	78.4	101
Rat	0.250	991	544	1049	774	37.8	0.0120	0.0020	0.00094	0.0021	0.233	24.4	24.7	97.6	99.0
Mustela erminea	0.259	982	541	1044	772	37.5	0.0100	0.0057	0.0025	0.0023	0.238	26.2	25.4	101	98.1
Helogale parvula	0.260	981	541	1044	772	37.5	0.0111	0.0052	0.0015	0.0025	0.240	26.1	25.5	100	98.0
Sciurus vulgaris	0.275	967	537	1037	768	37.2	0.0055	0.0063	0.0017	0.0017	0.259	21.4	26.6	77.9	96.7
Callithrix jacchus	0.312	935	527	1022	760	36.4	0.0178	0.0073	0.0028	0.0029	0.281	35.8	29.2	115	93.7
Saguinus fuscicollis; lagonotus	0.330	920	523	1015	756	36.0	0.0144	0.0078	0.0033	0.0019	0.303	33.0	30.5	100	92.4
Rat	0.337	915	521	1012	755	35.9	0.0080	0.0019	0.0010	0.0023	0.324	22.7	31.0	67.3	91.9
Rat (Wistar)	0.390	880	511	995	746	35.1	0.0143	0.0019	0.0011	0.0028	0.370	29.8	34.6	76.3	88.6
Sciurus niger	0.412	867	507	989	743	34.7	0.0107	0.0075	0.0025	0.0030	0.389	31.3	36.0	75.8	87.4
Sciurus carolinensis	0.596	786	481	946	720	32.7	0.0164	0.0075	0.0028	0.0032	0.566	40.0	47.5	67.1	79.7
Saguinus oedipus	0.624	776	478	941	717	32.4	0.0209	0.0100	0.0037	0.0031	0.586	45.7	49.1	73.2	78.8
Mustela putorius	0.640	771	476	939	716	32.3	0.0288	0.0104	0.0048	0.0040	0.592	53.6	50.1	83.8	78.3
Leontopithecus chrysomelas	0.642	770	476	938	716	32.3	0.0189	0.0132	0.0038	0.0041	0.602	46.8	50.2	73.0	78.2
Guinea pig	0.800	726	461	914	703	31.1	0.0270	0.0047	0.0023	0.0056	0.760	51.5	59.2	64.3	74.0
Potorous tridactylus	0.809	724	460	913	702	31.0	0.0237	0.0114	0.0048	0.0062	0.763	54.8	59.7	67.8	73.8
Erinaceus europaeus	0.950	693	450	896	693	30.2	0.0496	0.0043	0.0055	0.0089	0.881	74.1	67.3	78.0	70.9
Sylvilagus floridanus	0.972	689	448	893	691	30.1	0.0320	0.0079	0.0048	0.0063	0.921	61.9	68.5	63.7	70.5
Ondatra zibethicus	0.991	686	447	891	690	30.0	0.0260	0.0047	0.0030	0.0058	0.952	55.1	69.5	55.6	70.2
Saimiri boliviensis	1.00	683	446	890	690	29.9	0.0194	0.0290	0.0065	0.0067	0.941	64.8	70.2	64.6	69.9
Martes foina	1.41	624	425	855	670	28.3	0.0349	0.0190	0.0098	0.0073	1.335	81.0	90.4	57.6	64.3
Mephitis mephitis	1.45	619	424	852	669	28.2	0.0174	0.0098	0.0060	0.0066	1.409	64.2	92.5	44.3	63.8
Trichosurus vulpecula	1.55	608	420	845	665	27.9	0.0332	0.0127	0.0090	0.0135	1.482	83.3	97.2	53.7	62.7
Martes martes	1.60	603	418	842	663	27.7	0.0379	0.0205	0.0108	0.0088	1.525	88.6	99.7	55.3	62.2
Cebus apella	1.75	589	412	833	658	27.3	0.0493	0.0508	0.0134	0.0104	1.626	112	107	64.2	60.9
Eulemur macaco macaco	1.88	578	408	827	655	27.0	0.0778	0.0242	0.0091	0.0142	1.750	119	112	63.4	59.8
Chrotagale owstoni	1.96	571	406	822	652	26.8	0.0441	0.0233	0.0116	0.0128	1.868	103	116	52.3	59.2
Vulpes corsac	2.08	563	403	817	649	26.5	0.0356	0.0341	0.0217	0.0088	1.975	110	121	52.8	58.3
Lemur catta	2.08	563	403	817	649	26.5	0.0729	0.0228	0.0117	0.0112	1.956	119	121	57.3	58.3
Eulemur fulvus fulvus	2.50	535	392	799	639	25.7	0.0434	0.0225	0.0118	0.0095	2.413	110	139	43.8	55.7
Felis silvestris	2.57	531	390	796	638	25.6	0.0502	0.0381	0.0103	0.0154	2.459	122	142	47.6	55.3
Didelphis virginiana	2.63	528	389	794	636	25.5	0.1573	0.0083	0.0121	0.0229	2.433	172	145	65.5	54.9
Aonyx cinerea	2.68	526	388	793	635	25.4	0.1064	0.0359	0.0151	0.0306	2.487	165	146	61.5	54.7
Leopardus geoffroyi	3.10	505	380	779	628	24.8	0.0584	0.0321	0.0160	0.0307	2.963	147	164	47.4	52.8
Lepus europaeus	3.34	495	376	772	624	24.5	0.0904	0.0148	0.0289	0.0185	3.186	162	173	48.6	51.8
Dasyprocta punctata	3.40	493	375	771	623	24.4	0.1088	0.0228	0.0363	0.0213	3.211	182	175	53.5	51.5
Potos flavus	3.92	474	368	758	616	23.9	0.1657	0.0311	0.0211	0.0144	3.688	203	195	51.8	49.7
Dasyprocta azarae	4.10	469	365	754	613	23.7	0.0935	0.0238	0.0304	0.0227	3.930	182	202	44.5	49.2
Varecia rubra	4.20	466	364	752	612	23.6	0.0722	0.0357	0.0181	0.0224	4.052	170	205	40.4	48.9
Alouatta sara	4.40	460	362	747	610	23.4	0.0812	0.0565	0.0240	0.0099	4.228	181	213	41.1	48.3
Monkey	4.50	457	361	745	609	23.3	0.110	0.0420	0.0230	0.0210	4.304	196	216	43.5	48.1
Martes pennanti	4.79	450	357	740	605	23.1	0.113	0.0412	0.0274	0.0211	4.588	204	227	42.7	47.3
Trachypithecus vetulus	5.00	445	355	736	603	22.9	0.090	0.0720	0.0192	0.0154	4.803	199	234	39.8	46.8
Lutrogale perspicillata	5.10	442	354	734	602	22.8	0.152	0.0622	0.0485	0.0485	4.789	263	238	51.6	46.6
Chlorocebus pygerythrus	5.30	438	352	731	600	22.7	0.089	0.0808	0.0426	0.0121	5.076	221	245	41.7	46.1
Lutra lutra	5.33	437	352	731	600	22.7	0.255	0.0478	0.0514	0.0611	4.910	314	245	58.9	46.1
Proteles cristata	5.40	435	351	730	599	22.6	0.182	0.0399	0.0906	0.0243	5.063	288	248	53.4	45.9
Agouti paca	5.46	434	351	729	599	22.6	0.140	0.0321	0.0176	0.0222	5.248	217	250	39.7	45.8
Macaca nigra	5.60	431	350	726	598	22.5	0.095	0.1052	0.0239	0.0186	5.357	227	255	40.5	45.5
Puma yagouaroundi	5.90	425	347	722	595	22.3	0.116	0.0430	0.0296	0.0391	5.673	235	265	39.9	44.9
Hylobates concolor	6.55	414	342	713	590	21.9	0.293	0.1378	0.0582	0.0352	6.026	363	287	55.3	43.8
Prionailurus viverrinus	7.30	402	337	704	584	21.5	0.160	0.0529	0.0335	0.0559	6.998	289	311	39.6	42.6
Macropus agilis	7.70	396	334	700	582	21.3	0.203	0.0308	0.0602	0.0463	7.360	317	324	41.1	42.0
Lontra canadensis	7.90	393	333	697	581	21.2	0.255	0.0425	0.0541	0.0747	7.474	354	330	44.8	41.8
Dolichotis patagonum	8.43	387	330	692	578	21.0	0.158	0.0365	0.0651	0.0360	8.134	310	346	36.8	41.1
Symphalangus syndactylus	8.50	386	329	691	577	21.0	0.294	0.1430	0.0515	0.0437	7.968	388	348	45.7	41.0
Colobus guereza	9.75	372	323	680	571	20.5	0.171	0.0865	0.0370	0.0233	9.432	323	386	33.2	39.6
Felis chaus	9.80	371	323	680	570	20.5	0.153	0.0497	0.0483	0.0819	9.467	346	388	35.3	39.6
Lynx canadensis	10.0	369	322	678	569	20.4	0.158	0.0826	0.0388	0.0549	9.666	340	394	34.0	39.4
Dog	10.0	369	322	678	569	20.4	0.420	0.0750	0.0850	0.0700	9.350	468	394	46.8	39.4
Arctictis binturong	10.3	366	320	676	568	20.3	0.915	0.0605	0.0752	0.0513	9.198	621	402	60.3	39.1
Hystrix indica	11.3	358	316	669	564	20.0	0.255	0.0407	0.0562	0.0524	10.85	388	430	34.5	38.2
Theropithecus gelada	11.4	357	316	668	563	20.0	0.236	0.1409	0.0772	0.0380	10.91	419	434	36.8	38.1
Pudu puda	13	345	310	658	557	19.6	0.206	0.0616	0.0505	0.0199	12.56	380	476	29.5	36.9
Gazella gazella	15	331	304	647	550	19.1	0.327	0.0793	0.120	0.0406	14.43	508	534	33.8	35.6
Castor fiber	15.6	328	302	644	549	19.0	0.345	0.0489	0.044	0.0783	15.05	485	548	31.1	35.2
Macaca arctoides	15.9	326	301	642	548	18.9	0.241	0.1180	0.061	0.0500	15.40	472	556	29.7	35.1
Lynx lynx	17.5	318	297	635	543	18.6	0.264	0.0943	0.093	0.0795	16.97	529	599	30.3	34.2
Capreolus capreolus	20	307	292	625	537	18.2	0.480	0.100	0.160	0.0800	19.18	668	662	33.4	33.1
Cuon alpinus	20.0	307	292	625	537	18.2	0.346	0.116	0.158	0.0764	19.30	631	662	31.5	33.1
Dog	20.4	305	291	624	537	18.1	0.447	0.096	0.153	0.0920	19.6	665	672	32.6	32.9
Mandrillus sphinx	23.0	295	286	615	531	17.8	0.331	0.168	0.076	0.0499	22.4	616	735	26.8	32.0
Papio hamadryas	23.3	295	285	614	531	17.7	0.392	0.174	0.103	0.0803	22.5	670	741	28.8	31.9
Zalophus californianus	34.0	266	270	587	514	16.6	1.274	0.310	0.168	0.2059	32.0	1161	986	34.1	29.0
Hydrochaeris hydrochaeris	34.0	266	270	587	514	16.6	0.696	0.084	0.104	0.1035	33.0	872	986	25.6	29.0
Canis lupus chanco	38.0	258	266	579	509	16.3	0.971	0.140	0.303	0.2069	36.4	1163	1071	30.6	28.2
Sheep	52	237	255	558	496	15.5	0.960	0.106	0.280	0.160	50.5	1274	1356	24.5	26.1
Reference women	58	200	240	440	440	10.4	1.40	1.20	0.240	0.275	54.9	1365	1471	23.5	25.4
Human	60	200	240	440	440	10.4	1.70	1.30	0.320	0.250	56.4	1490	1509	24.8	25.2
Reference man	70	200	240	440	440	10.4	1.80	1.40	0.330	0.310	66.2	1666	1694	23.8	24.2
Panthera tigris altaica	75	215	242	535	481	14.6	1.10	0.342	0.305	0.4246	72.8	1750	1784	23.3	23.8
Hog	125	188	225	503	461	13.4	1.60	0.12	0.350	0.260	123	2267	2617	18.1	20.9
Dairy cow	488	130	185	429	412	10.7	6.46	0.40	1.88	1.16	478	7304	7268	15.0	14.9
Horse	600	123	180	418	405	10.3	6.70	0.67	4.25	1.66	587	9449	8486	15.7	14.1
Steer	700	118	176	411	400	10.1	5.00	0.50	2.30	1.00	691	8973	9526	12.8	13.6
Elephant	6650	65	128	315	331	6.9	6.30	5.70	2.20	1.20	6635	48054	51548	7.2	7.8

Source of 𝑀 and 𝑇_𝑖 data: mouse and dog (𝑀 = 20.42 kg) from Marting and Fuhrman, 1955 [9]; rat, guinea pig, dog (𝑀 = 10 kg), sheep, hog, dairy cow, horse, steers, and elephant from Elia, 1992 [7]; reference man and woman from Snyder et al., [10]; rest species from Navarrete et al., 2011 [11].
Abbreviations: 𝑀: body mass (in kg); 𝐾𝐿,𝐾𝐵,𝐾𝐻,𝐾𝐾, and 𝐾𝑅: Specific resting metabolic rate of liver, brain, heart, kidney, and residuals, respectively (all in kcal/kg per day); 𝑇𝐿,𝑇𝐵,𝑇𝐻,𝑇𝐾, and 𝑇𝑅: mass of liver, brain, heart, kidney, and residuals, respectively (all in kg); REE_𝑝: resting energy expenditure predicted by the organ-tissue level REE model (in kcal/day); REE_𝑘: resting energy expenditure calculated by Kleiber’s Law (in kcal/day); (REE/𝑀)_𝑝: the ratio of resting energy expenditure by the organ-tissue level REE model to body mass (in kcal/kg per day); (REE/𝑀)_𝑘: the ratio of resting energy expenditure calculated by Kleiber’s Law to body mass (in kcal/kg per day).