Table of Contents
ISRN Analytical Chemistry
Volume 2012, Article ID 673564, 6 pages
http://dx.doi.org/10.5402/2012/673564
Research Article

Improvement of Water Solubility of Josamycin by Inclusion Complex with 𝜸 -Cyclodextrin

1Medicinal Chemistry Research Team, Faculty of Medicine and Pharmacy, University Mohammed V, Souissi, BP 6203, Rabat, Morocco
2Pharmaceutical and Toxicological analysis Research Team, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V, Souissi, BP 6203, Rabat, Morocco
3Centre de Recherche en Epidémiologie Clinique et Essais thérapeutiques, Faculty of Medicine and Pharmacy, University Mohammed V, Souissi, BP 6203, Rabat, Morocco

Received 2 November 2011; Accepted 20 November 2011

Academic Editors: D. Heimler and V. Stefov

Copyright © 2012 J. El Harti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Josamycin propionate (JMP) is an antibiotic belonging to the family of macrolide. According to the Biopharmaceutical Classification System (BCS), this compound can be classed in class II, low solubility and high permeability. In order to increase its apparent water solubility, inclusion complexation between Josamycin propionate and γ-cyclodextrin (γ-CD) was studied. UV spectrophotometric method was employed to investigate the phase-solubility profile and the stability constant of the complexation in aqueous medium. Solid state of the binary system prepared by coevaporation (in 50%-50% ethanol/water) has been characterized using powder X-ray diffraction (XRD) and Fourier transformation-infrared spectrometry (FTIR). These techniques indicate that JMP forms an association complex with γ-CD. The shift in the nuclear magnetic resonance spectroscopy (1H NMR) confirms the existence of the inclusion complex. Also the results obtained showed an enhancement of the solubility in water of Josamycin propionate.