Table of Contents
ISRN Endocrinology
Volume 2012, Article ID 691803, 5 pages
http://dx.doi.org/10.5402/2012/691803
Clinical Study

The Association of Hypovitaminosis D with the Metabolic Syndrome Is Independent of the Degree of Obesity

1Endocrinology and Nutrition Department, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
2Medicine Department, Universitat Autònoma de Barcelona (UAB), 08193 Bellaterra, Spain
3Diabetes and Metabolic Diaseases CIBER, CIBERDEM, Sant Antoni maria Claret 167, 08025 Barcelona, Spain
4Biomedical Research Institute (IIB Sant Pau), Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
5Clinical Biochemistry Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Sant Antoni Maria Claret 167, 08025 Barcelona, Spain
6Bioengineering, Biomaterials and Nanomedicine CIBER, CIBERBBN, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain

Received 6 September 2012; Accepted 23 September 2012

Academic Editors: E. Blázquez, T. W. Furlanetto, G. Garruti, and J. Vrbikova

Copyright © 2012 Inka Miñambres et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. It remains uncertain whether the metabolic syndrome (MS) or insulin resistance contribute to the association between vitamin D deficiency and obesity. Methods. We conducted a cross-sectional survey of 343 subjects who were overweight or obese. We analyzed anthropometric data and the presence or absence of MS. Additionally, we determined 25-hydroxyvitamin D (25OHD) and insulin concentrations, and the HOMA index was calculated. Chi-square test,Mann-Whitney U test, Student's t-tests,and logistic regression analysis were used. Results. The mean age of the patients was years, and 65.9% were women. The mean BMI was  kg/m2 and 25(OH)D levels were  nmol/L. Forty-six patients (13.4%) had MS. Vitamin D status was associated with the degree of obesity, especially with a BMI > 40 kg/m2. Patients with MS had lower levels of 25(OH)D than patients without ( versus  mmol/L, resp.), and the odds ratio for hypovitaminosis D was 2.7 (confidence interval (CI), 1.14–6.4) ( ) for patients with MS versus patients without MS, irrespective of the degree of obesity. Conclusions. Our data confirm the association between vitamin D and MS and suggest that this association is independent of the degree of obesity.