Table of Contents
ISRN Spectroscopy
Volume 2012, Article ID 697156, 9 pages
http://dx.doi.org/10.5402/2012/697156
Research Article

Differentiation between 6- and 7-Membered Rings Based on Theoretical Calculation of NMR Parameters

Department of Chemistry, University of Turku, Vatselankatu 2, 20014 Turku, Finland

Received 29 August 2012; Accepted 3 October 2012

Academic Editors: J. Casado, J.-H. Choi, D. Ferri, I. P. Gerothanassis, G. S. Kumar, and J. M. Saniger

Copyright © 2012 Karel D. Klika. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The determination of ring size can vary from simple to complex, but the process in difficult cases can be advantageously augmented by DFT calculation of NMR parameters such as the chemical shifts of ( ), ( ), and other nuclei as well as pertinent spin-spin (scalar) coupling constants, for example, those between protons ( ). Differentiation between 6- and 7-membered ring formation in the case of 3,4-dihydro-2H-3-hydroxymethyl-1,4-benzoxazine and 2,3,4,5-tetrahydro-1,5-benzoxazepine-3-ol was evaluated with a view to not only affecting 6- versus 7-membered ring differentiation generally for cases on hand, but also in the case of literature reports where the assigned structures may be in doubt. Thus, the main focus was on the usually reported NMR parameters of , , and and wherein the analysis was found to be highly successful, particularly for , and thus potentially amenable for broad application.