The -1364A/C Aquaporin 5 Gene Promoter Polymorphism Is Not Associated with Menière’s Disease
Table 2
(a) Genotype frequencies of the A(-1364)C-AQP5 polymorphism in patients with endolymphatic hydrops (EH), familial Menière’s disease (FMD), and Menière’s disease (MD) and in healthy controls. (b) Genotype frequencies of the A(-1364)C-AQP5 polymorphism in patients with different grades of EH and Menière’s disease according to AAO-HNS.
(a)
Genotypes/alleles/entities
AA
AC
CC
value
A
C
value
(%)
(%)
(%)
(%)
(%)
EH
8
1
0
0.352
17
1
0.334
(88.9)
(11.1)
0
(94.4)
(5.6)
MD
23
12
1
0.391
58
14
0.498
(63.9)
(33.3)
(2.8)
(80.6)
(19.4)
FMD
37
11
3
0.042
*
85
17
0.884
(72.5)
(21.6)
(5.9)
(82.7)
(17.3)
Controls
202
87
3
491
93
(69.9)
(30)
(1)
84.1
(15.9)
values refer to statistical significance () of genotype frequencies within the particular groups of EH, MD, and FMD. value of CC in the FMD group (0.042) is considered as statistically significant.
