Table of Contents
ISRN Obstetrics and Gynecology
Volume 2012 (2012), Article ID 709464, 6 pages
http://dx.doi.org/10.5402/2012/709464
Clinical Study

Flow-Mediated Vasodilation Is Not Attenuated in Hypertensive Pregnancies Despite Biochemical Signs of Inflammation

1Department of Ob/Gyn, Kuopio University Hospital, University of Eastern Finland, 70211 Kuopio, Finland
2Laboratory Centre, Kuopio University Hospital, University of Eastern Finland, 70211 Kuopio, Finland
3Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, University of Eastern Finland, 70211 Kuopio, Finland

Received 25 October 2011; Accepted 4 December 2011

Academic Editor: C. Battaglia

Copyright Β© 2012 Heli Saarelainen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Our objective was to evaluate endothelial function and markers of inflammation during and after pregnancy in normal pregnancies compared to pregnancies complicated with hypertension or preeclampsia (PE). Methods and Results. We measured endothelium-dependent brachial artery flow-mediated vasodilation (FMD) and high sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α) in 32 women with normal pregnancy and in 28 women whose pregnancy was complicated with hypertensive disorder in the second half of pregnancy and minimum 3-month postpartum. Enhancement of endothelial function was greater in hypertensive than normal pregnancies, the mean FMD% being 11.0% versus 8.8% during pregnancy ( 𝑃 = 0 . 1 9 4 ) and 8.0% versus 7.9% postpartum ( 𝑃 = 0 . 9 7 8 ). Concentrations of markers of inflammation were markedly increased in pregnant hypertensive group compared to those after delivery (hsCRP 4.5 versus 0.80 mg/L, 𝑃 = 0 . 0 2 3 , IL-6 2.1 versus 1.2 pg/mL, 𝑃 = 0 . 0 0 6 ; TNF-α 1.9 versus 1.5 pg/mL, 𝑃 = 0 . 0 3 0 ). There were no statistically significant associations between the markers of inflammation and FMD. Conclusions. Brachial artery FMD was not attenuated in the third trimester hypertensive pregnancies compared to normal pregnancies, whereas circulating concentrations of hsCRP and IL-6 and TNF-α reacted to hypertensive complications.