International Scholarly Research Notices

Review Article

Peroxisome Dynamics: Molecular Players, Mechanisms, and (Dys)functions

Table 1

List of peroxins identified to date. Peroxins described in mammals are shown in bold. Note that mammalian genomes encode three Pex11 proteins: Pex11p , Pex11p , and Pex11p . All abbreviations are defined in the “Abbreviations” section.
PeroxinFeaturesFunctions
Pex1pAAA-ATPasePex5p recycling, fusion of preperoxisomal vesicles
Pex2pPMP, RING domainSubunit of the E3 complex for polyubiquitination of Pex5p
Pex3pPMPDocking factor for Pex19p, initiation of macropexophagy
Pex4pPeripheral PMPSubunit of the E2 complex of for monoubiquitination of Pex5p
Pex5pTPR proteinPTS1 import receptor, PTS2 coreceptor
Pex6pAAA-ATPasePex5p recycling, fusion of pre-peroxisomal vesicles
Pex7pWD40 proteinPTS2 receptor
Pex8pPeripheral PMPPex5p-cargo release factor? Organizer of the protein import machinery?
Pex9p Erroneously identified open reading frame
Pex10pPMP, RING domainSubunit of the E3 complex for mono- and polyubiquitination of Pex5p
Pex11p(peripheral) PMPPeroxisome elongation factor (peroxisome proliferation)
Pex12pPMP, RING domainSubunit of the E3 complex for monoubiquitination of Pex5p
Pex13pPMP, SH3 domainSubunit of the PTS-receptor docking complex
Pex14pPMPSubunit of the PTS-receptor docking complex, initiation of macropexophagy
Pex15pPMPDocking factor for Pex6p
Pex16pPMPDocking factor for Pex3p
Pex17pPMPSubunit of the PTS-receptor docking complex
Pex18p PTS2 co-receptor
Pex19pFarnesylation motifChaperone and import receptor for PMPs
Pex20p PTS2 co-receptor
Pex21p PTS2 co-receptor
Pex22pPMPSubunit of the E2 complex of for monoubiquitination of Pex5p
Pex23pPMPPeroxisome proliferation
Pex24pPMPPeroxisome proliferation
Pex25pPMPPeroxisome proliferation
Pex26pPMPDocking factor for Pex6p
Pex27pPMPPeroxisome proliferation
Pex28pPMPPeroxisome proliferation
Pex29pPMPPeroxisome proliferation
Pex30pPMP, dysferlin domainPeroxisome proliferation
Pex31pPMP, dysferlin domainPeroxisome proliferation
Pex32pPMPPeroxisome proliferation
Pex33pPMPSubunit of the PTS-receptor docking complex
Pex34pPMPPeroxisome proliferation