The Toxic Effects of Polychemotherapy onto the Liver Are Accelerated by the Upregulated MDR of Lymphosarcoma
Figure 1
Experimental schemes of the treatment of mice bearing RLS40. Scheme 1: tumor-bearing mice were exposed to polychemotherapy (passage 1) followed by preparation of primary tumor cell culture, implantation of these cells into healthy animals, and repeated polychemotherapy (passages 2, 3, and 4). Scheme 2: tumor-bearing mice was exposed to three subsequent courses of polychemotherapy.
