Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

<table>Effect of amounts of HPMC K4M and Carbopol 943 on hardness (kg/cm<sup>2</sup>)  presented by response surface plot (a), and contour plot (b).</table>

International Scholarly Research Notices

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Figure 8

Figure 8: Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release 