Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release
Table 3
Summary of ANOVA for response parameters.
Source
Sum of square
d.f.a
Mean square
value
value prob >
For 6h (%)b
Model
593.77
6
98.96
2714.99
0.0147 (S)
98.84
1
98.84
2711.71
0.0122 (S)
323.09
1
323.09
8863.87
0.0068 (S)
157.18
1
157.18
4312.11
0.0097 (S)
1.94
1
1.94
53.24
0.0867 (NS)
5.58
1
5.58
153.08
0.0514 (NS)
7.14
1
7.14
196.00
0.0454 (S)
For hardness (kg/cm2)
Model
0.85
6
0.14
454.17
0.0359 (S)
0.10
1
0.10
302.76
0.0365 (S)
0.12
1
0.12
392.04
0.0321 (S)
0.58
1
0.58
1849.00
0.0148 (S)
2.81 × 10−3
1
2.81 × 10−3
9.00
0.2048 (NS)
0.05
1
0.05
169.00
0.0489 (S)
1.01 × 10−3
1
1.01 × 10−3
3.24
0.3228 (NS)
ad.f. indicates degree of freedom; b6h (%): cumulative drug release after 6 hours; , , and represent the main effects (factors)—the amount of calcium alginate, HPMC K4M, and Carbopol 943 in mg, respectively; , , and are their interaction effects; S and NS indicate significance and nonsignificance, respectively.
