International Scholarly Research Notices / 2012 / Article / Tab 3

Research Article

Use of Response Surface Methodology in the Formulation and Optimization of Bisoprolol Fumarate Matrix Tablets for Sustained Drug Release

Table 3

Summary of ANOVA for response parameters.

SourceSum of squared.f.aMean square value value
prob >

For 6h (%)b
 Model593.776 98.962714.990.0147 (S)
98.841 98.842711.710.0122 (S)
323.091323.098863.870.0068 (S)
157.181157.184312.110.0097 (S)
1.941 1.94 53.24 0.0867 (NS)
5.581 5.58153.08 0.0514 (NS)
7.141 7.14196.000.0454 (S)

For hardness (kg/cm2)
 Model0.8560.14 454.170.0359 (S)
0.1010.10 302.760.0365 (S)
0.1210.12 392.040.0321 (S)
0.5810.581849.000.0148 (S)
2.81 × 10−312.81 × 10−3 9.00 0.2048 (NS)
0.0510.05169.000.0489 (S)
1.01 × 10−311.01 × 10−3 3.24 0.3228 (NS)

ad.f. indicates degree of freedom; b 6h (%): cumulative drug release after 6 hours; , , and represent the main effects (factors)—the amount of calcium alginate, HPMC K4M, and Carbopol 943 in mg, respectively; , , and are their interaction effects; S and NS indicate significance and nonsignificance, respectively.

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